All Phenotypes St14<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

St14⁺
wild type
MGI:2437719

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	St14^{Gt(RST485)Byg}/St14⁺	involves: 129P2/OlaHsd * Black Swiss	MGI:3717473
ht2	St14^Gt(XM184)Byg/St14⁺	involves: 129P2/OlaHsd * Black Swiss	MGI:3717475
cx3	Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg} St14^tm1Bug/St14⁺	involves: 129P2/OlaHsd	MGI:5440264
cx4	F2rl1^tm1Cgh/F2rl1^tm1Cgh Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg} St14^tm1Bug/St14⁺	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:5440267
cx5	Spint1^tm1Bug/Spint1^tm1Bug St14^tm1Bug/St14⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac	MGI:5440270
cx6	Prss8^fr/Prss8^fr Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg} St14^tm1Bug/St14⁺	involves: 129P2/OlaHsd * DBA	MGI:5440275

Allelic Composition	St14^{Gt(RST485)Byg}/St14⁺
Genetic Background	involves: 129P2/OlaHsd * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
St14^{Gt(RST485)Byg} mutation (0 available); any St14 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired skin barrier function ( J:108567 )

• at E14.5 and E15.5, mice have reduced epithelial barrier function as measured by a dye assay

integument

impaired skin barrier function ( J:108567 )

• at E14.5 and E15.5, mice have reduced epithelial barrier function as measured by a dye assay

Allelic Composition	St14^Gt(XM184)Byg/St14⁺
Genetic Background	involves: 129P2/OlaHsd * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
St14^Gt(XM184)Byg mutation (0 available); any St14 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired skin barrier function ( J:108567 )

• at E14.5 and E15.5, mice have reduced epithelial barrier function as measured by a dye assay

integument

impaired skin barrier function ( J:108567 )

• at E14.5 and E15.5, mice have reduced epithelial barrier function as measured by a dye assay

Allelic Composition	Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg} St14^tm1Bug/St14⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spint2^{Gt(KST272)Byg} mutation (0 available); any Spint2 mutation (15 available)
St14^tm1Bug mutation (0 available); any St14 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:188121 )

• lethality at E10.5-E14.5

embryonic lethality during organogenesis, incomplete penetrance ( J:188121 )

• survive longer than embryos homozygous for Spint2^{Gt(KST272)Byg} alone

• lethality at E10.5-E14.5

embryonic lethality between implantation and placentation, incomplete penetrance ( J:188121 )

• 45% of embryos die at E9.5 or earlier

embryo

spina bifida ( J:188121 )

• in 95-100% of mice

abnormal placenta morphology ( J:188121 )

• placental defects

abnormal placenta labyrinth morphology ( J:188121 )

• incomplete differentiation

limbs/digits/tail

curly tail ( J:188121 )

• in 89% of mice

nervous system

spina bifida ( J:188121 )

• in 95-100% of mice

exencephaly ( J:188121 )

• in 11% of mice

Allelic Composition	F2rl1^tm1Cgh/F2rl1^tm1Cgh Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg} St14^tm1Bug/St14⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1^tm1Cgh mutation (3 available); any F2rl1 mutation (60 available)
Spint2^{Gt(KST272)Byg} mutation (0 available); any Spint2 mutation (15 available)
St14^tm1Bug mutation (0 available); any St14 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

exencephaly ( J:188121 )

• in all mice

• penetrance is identical to mutant mice wild-type for at least one F2rl1 allele

Allelic Composition	Spint1^tm1Bug/Spint1^tm1Bug St14^tm1Bug/St14⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spint1^tm1Bug mutation (0 available); any Spint1 mutation (26 available)
St14^tm1Bug mutation (0 available); any St14 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:188121 )

• at E10.5

embryo

absent placental labyrinth ( J:188121 )

Allelic Composition	Prss8^fr/Prss8^fr Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg} St14^tm1Bug/St14⁺
Genetic Background	involves: 129P2/OlaHsd * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss8^fr mutation (13 available); any Prss8 mutation (22 available)
Spint2^{Gt(KST272)Byg} mutation (0 available); any Spint2 mutation (15 available)
St14^tm1Bug mutation (0 available); any St14 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:188121 )

N	• expected numbers are found at term unlike mutant mice wild-type for St14

embryo

embryo phenotype ( J:188121 )

N	• complete rescue of neural tube closure and placental differentiation defects seen in mice homozygous for Spint2^{Gt(KST272)Byg} and heterozygous Prss8^fr

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