All Phenotypes Avil<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Avil⁺
wild type
MGI:2437523

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Avil^tm2(cre)Fawa/Avil⁺ Pik3c3^tm1Fawa/Pik3c3^tm1Fawa	involves: 129P2/OlaHsd	MGI:4460013
cn2	Ano1^tm1.1Jwo/Ano1^tm1.1Jwo Avil^tm2(cre)Fawa/Avil⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5461903
cn3	Gm34583^tm1.1Bcgen/Gm34583^tm1.1Bcgen Avil^tm2(cre)Fawa/Avil⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:7334895
cn4	Ntrk2^tm4.1Ddg/Ntrk2^tm4.1Ddg Avil^tm2(cre)Fawa/Avil⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:5617021
cn5	Atg7^tm1Tchi/Atg7^tm1Tchi Avil^tm2(cre)Fawa/Avil⁺	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:4460014
cn6	Avil^tm2(cre)Fawa/Avil⁺ Prdm12^tm1.1Ejbd/Prdm12^tm1.1Ejbd	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N	MGI:6387033

Allelic Composition	Avil^tm2(cre)Fawa/Avil⁺ Pik3c3^tm1Fawa/Pik3c3^tm1Fawa
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Avil^tm2(cre)Fawa mutation (2 available); any Avil mutation (45 available)
Pik3c3^tm1Fawa mutation (0 available); any Pik3c3 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:160568 )

• all mice die within 2 weeks of age

nervous system

increased neuron apoptosis ( J:160568 )

• at P5 and P9

abnormal sensory neuron morphology ( J:160568 )

• at P9, sensory neurons exhibit an increase in lysosome-like organelles unlike wild-type cells

• sensory neurons contain numerous large vacuoles unlike wild-type cells

decreased sensory neuron number ( J:160568 )

• at P5, 27% of sensory neurons are lost compared to in wild-type mice

• at P5 and P6, the numbers of TrkB+ and TrkC+ neurons are reduced compared to in wild-type mice

• at P9, only 44% of sensory neurons remain compared to in wild-type mice

• at P9, the numbers of TrkB+ and TrkC+ neurons are reduced compared to in wild-type mice

• at P9, the number of cRet+ neurons is moderately reduced compared to in wild-type mice

• during the early postnatal period, large-diameter mechanosensory and proprioceptive sensory neurons are lost unlike in wild-type mice

abnormal proprioceptive neuron morphology ( J:160568 )

• during the early postnatal period, large-diameter mechanosensory and proprioceptive sensory neurons are lost unlike in wild-type mice

neurodegeneration ( J:160568 )

• at P5, mice exhibit rapid degeneration of mature sensory neuron unlike wild-type mice

• during the early postnatal period, large-diameter mechanosensory and proprioceptive sensory neurons are lost unlike in wild-type mice

axon degeneration ( J:160568 )

• at P9, proprioceptive sensory axon projections to the ventral spinal cord are almost completely degenerated unlike in wild-type mice

• touch sensory innervations of layers III/IV are reduced compared to in wild-type mice

• large diameter myelinated axons exhibit degeneration unlike in wild-type mice

• however, small diameter unmyelinated axons are intact

behavior/neurological

impaired coordination ( J:160568 )

• at P5 to P6

abnormal posture ( J:160568 )

• at P5 to P6, mice exhibit difficulty in maintaining body posture unlike wild-type mice

hindlimb paralysis ( J:160568 )

• at P5 to P6, mice begin to drag their hindlimbs unlike wild-type mice

cellular

increased neuron apoptosis ( J:160568 )

• at P5 and P9

Allelic Composition	Ano1^tm1.1Jwo/Ano1^tm1.1Jwo Avil^tm2(cre)Fawa/Avil⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ano1^tm1.1Jwo mutation (0 available); any Ano1 mutation (58 available)
Avil^tm2(cre)Fawa mutation (2 available); any Avil mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:191353 )

N	• mice exhibit normal balance, motor coordination, locomotion and mechanical sensitivities

increased thermal nociceptive threshold ( J:191353 )

• in response to tail immersion in hot water or radiant heat

nervous system

abnormal sensory neuron morphology ( J:191353 )

• dorsal root ganglion sensory neurons exhibit reduced heat-evoked inward chloride current compared with control neurons

integument

integument phenotype ( J:191353 )

N	• mice exhibit normal mechanical sensitivities

Allelic Composition	Gm34583^tm1.1Bcgen/Gm34583^tm1.1Bcgen Avil^tm2(cre)Fawa/Avil⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Avil^tm2(cre)Fawa mutation (2 available); any Avil mutation (45 available)
Gm34583^tm1.1Bcgen mutation (0 available); any Gm34583 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hypoalgesia ( J:326871 )

• following L4 spinal nerve ligation-induced, mice exhibit mitigated nerve injury-induced mechanical, heat, and cold nociceptive hypersensitivities with reduced paw withdrawal percentage compared with control mice

homeostasis/metabolism

decreased susceptibility to injury ( J:326871 )

Allelic Composition	Ntrk2^tm4.1Ddg/Ntrk2^tm4.1Ddg Avil^tm2(cre)Fawa/Avil⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Avil^tm2(cre)Fawa mutation (2 available); any Avil mutation (45 available)
Ntrk2^tm4.1Ddg mutation (0 available); any Ntrk2 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal mammary gland sensory innervation pattern ( J:192549 )

• at E13, female mice exhibit reduced sensory neurons innervation of the mammary gland rudiments compared with wild-type mice

endocrine/exocrine glands

abnormal mammary gland sensory innervation pattern ( J:192549 )

• at E13, female mice exhibit reduced sensory neurons innervation of the mammary gland rudiments compared with wild-type mice

integument

abnormal mammary gland sensory innervation pattern ( J:192549 )

• at E13, female mice exhibit reduced sensory neurons innervation of the mammary gland rudiments compared with wild-type mice

Allelic Composition	Atg7^tm1Tchi/Atg7^tm1Tchi Avil^tm2(cre)Fawa/Avil⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg7^tm1Tchi mutation (3 available); any Atg7 mutation (51 available)
Avil^tm2(cre)Fawa mutation (2 available); any Avil mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

gliosis ( J:160568 )

• at 9 months

increased neuron apoptosis ( J:160568 )

• at 9 months in the dorsal root ganglia

abnormal sensory neuron morphology ( J:160568 )

• at 9 months, neurons contain large inclusion bodies and numerous electron-dense organelles unlike in wild-type mice

neurodegeneration ( J:160568 )

• at 9 months, mice exhibit neurodegeneration of TrkA+, cRet+, TrkB+, and TrkC+ sensory neurons unlike in wild-type mice

behavior/neurological

limb grasping ( J:160568 )

• at 7 months

tremors ( J:160568 )

• between 7 and 9 months

bradykinesia ( J:160568 )

• at 7 months, mice exhibit reduced mobility compared with wild-type mice

• between 7 and 9 months, mice exhibit difficulties in movement unlike wild-type mice

limbs/digits/tail

curly tail ( J:160568 )

• between 7 and 9 months, mice develop stiffly twisted tails unlike wild-type mice

cellular

gliosis ( J:160568 )

• at 9 months

increased neuron apoptosis ( J:160568 )

• at 9 months in the dorsal root ganglia

Allelic Composition	Avil^tm2(cre)Fawa/Avil⁺ Prdm12^tm1.1Ejbd/Prdm12^tm1.1Ejbd
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Avil^tm2(cre)Fawa mutation (2 available); any Avil mutation (45 available)
Prdm12^tm1.1Ejbd mutation (0 available); any Prdm12 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased neuron apoptosis ( J:283226 )

• at E16.5 in the dorsal root ganglia

decreased sensory neuron number ( J:283226 )

• reduced neurons expressing nociception markers in the dorsal root ganglia at E15.5 and E18.5

• strongly reduced peptidergic and non-peptidergic projections in the dorsal horn

• reduced Islet1+ neurons in the dorsal root ganglia at E16.5

abnormal superior glossopharyngeal ganglion morphology ( J:283226 )

• reduced superior jugular ganglia at E14.5

small trigeminal ganglion ( J:283226 )

• at E14.5

cellular

increased neuron apoptosis ( J:283226 )

• at E16.5 in the dorsal root ganglia

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