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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Xirp1+
wild type
MGI:2437457
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Xirp1tm1Jl/Xirp1+ involves: 129 MGI:5906605


Genotype
MGI:5906605
ht1
Allelic
Composition
Xirp1tm1Jl/Xirp1+
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xirp1tm1Jl mutation (1 available); any Xirp1 mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• myofiber width is increased indicating cardiomyocyte hypertrophy
• thickening of the ventricular myocardial wall
• heart ventricles show increased trabeculation
• hearts are modestly enlarged at 9 months of age although the heart-to-body weight ratio only shows a trend toward enlargement
• hearts are enlarged, show thickening of the ventricular myocardial wall and increased trabeculae indicating cardiac hypertrophy
• increase in interstitial fibrosis at 14 months of age
• hypertrophic cardiomyopathy

muscle
• myofiber width is increased indicating cardiomyocyte hypertrophy
• thickening of the ventricular myocardial wall
• heart ventricles show increased trabeculation
• hypertrophic cardiomyopathy

growth/size/body
• hearts are modestly enlarged at 9 months of age although the heart-to-body weight ratio only shows a trend toward enlargement
• hearts are enlarged, show thickening of the ventricular myocardial wall and increased trabeculae indicating cardiac hypertrophy

cellular
• increase in interstitial fibrosis at 14 months of age





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/24/2026
MGI 6.24
The Jackson Laboratory