Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tlr4+ wild type MGI:2437431 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the index mouse, later genotyped and found to be heterozygous for the mutation, was identified on the basis of reduced interleukin (IL)-1 beta production in response to lipopolysaccharide (LPS)/nigericin
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• intermediate following exposure to lipopolysaccharide (LPS) and aluminum adjuvants
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• intermediate following exposure to lipopolysaccharide (LPS)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced TNF secretion from macrophages in response to lipolysaccharide (LPS)
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• reduced TNF secretion from macrophages in response to lipolysaccharide (LPS)
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• educed TNF secretion from macrophages in response to lipolysaccharide (LPS)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• some mice show reduced TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)
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• some mice show reduced TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)
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• some mice show reduced TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice showed slight reduction in TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)
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• some mice exhibited attenuated inflammatory responses related to decreased secretion of the proinflammatory cytokine interleukin (IL)-1 in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment
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• mice showed slight reduction in TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)
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• mcie showed a resistance to LPS-induced macrophage necroptosis
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• mice showed a resistance to LPS-induced macrophage necroptosis
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• mice showed slight reduction in TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice showed slight reduction in TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)
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• some mice also exhibited attenuated inflammatory responses related to decreased secretion of the proinflammatory cytokine interleukin (IL)-1 in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment
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• mice showed slight reduction in TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)
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• mice showed resistance to LPS-induced macrophage necroptosis
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• mice showed resistance to LPS-induced macrophage necroptosis
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• mice showed slight reduction in TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/18/2025 MGI 6.24 |
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