Phenotypes associated with this allele

• Allele Symbol: Tulp3⁺
• Allele Name: wild type
• Allele ID: MGI:2437390
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tulp3^tm1b(EUCOMM)Hmgu/Tulp3^+	C57BL/6N-Tulp3^tm1b(EUCOMM)Hmgu/H	MGI:5757835
ht2	Tulp3^tm1Jng/Tulp3^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:2654883
ht3	Tulp3^hhkr/Tulp3^+	involves: C3H/HeH * C57BL/6	MGI:3842139
cn4	Tulp3^tm1c(EUCOMM)Hmgu/Tulp3^+ Pkd1^tm2Ggg/Pkd1^tm2Ggg Tg(Pax8-rtTA2S*M2)1Koes/0 Tg(tetO-cre)1Jaw/0	involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA * SJL	MGI:6392330
cx5	Gli3^Xt-J/Gli3^+ Tulp3^hhkr/Tulp3^+	involves: C3H/HeH * C3H/HeJ * C57BL/6	MGI:3842144
cx6	Gli3^Xt-J/Gli3^Xt-J Tulp3^hhkr/Tulp3^+	involves: C3H/HeH * C3H/HeJ * C57BL/6	MGI:3842146

Genotype
MGI:5757835

ht1

• Allelic Composition: Tulp3^{tm1b(EUCOMM)Hmgu}/Tulp3⁺
• Genetic Background: C57BL/6N-Tulp3^{tm1b(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0508_5_B01

Data Sources

IMPC Data for Tulp3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:211773 )

♂

IMPC - HAR

growth/size/body

decreased lean body mass ( J:211773 )

♂

IMPC - HAR

homeostasis/metabolism

increased circulating bilirubin level ( J:211773 )

IMPC - HAR

decreased fasting circulating glucose level ( J:211773 )

♀

IMPC - HAR

increased circulating alanine transaminase level ( J:211773 )

♀

IMPC - HAR

increased circulating aspartate transaminase level ( J:211773 )

♀

IMPC - HAR

impaired glucose tolerance ( J:211773 )

♂

IMPC - HAR

nervous system

decreased prepulse inhibition ( J:211773 )

♂

IMPC - HAR

Genotype
MGI:2654883

ht2

• Allelic Composition: Tulp3^tm1Jng/Tulp3⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

mortality/aging

embryonic lethality, incomplete penetrance ( J:70060 )

• affected heterozygous mutant embryos exhibit embryonic lethality with excessive neuroepithelial apoptosis in the hindbrain

• however, no overt abnormalities are detected in live-born heterozygous mutant mice

nervous system

increased embryonic neuroepithelium apoptosis ( J:70060 )

• at E10.5, affected heterozygous mutant embryos display excessive apoptosis of neuroepithelial cells in the hindbrain region

open neural tube ( J:70060 )

• at E10.5, a few heterozygotes exhibit an open neural tube

abnormal brain morphology ( J:70060 )

• at E10.5, 18% of heterozygous mutant embryos display an abnormal brain phenotype that is less severe than that observed in homozygous mutant embryos

abnormal brain development ( J:70060 )

• at E10.5, the majority of affected heterozygous mutant embryos display abnormal fore-, mid- and hindbrain development

abnormal midbrain morphology ( J:70060 )

• at E10.5, affected heterozygotes exhibit an underdeveloped and disorganized midbrain

abnormal forebrain morphology ( J:70060 )

• at E10.5, affected heterozygotes exhibit an underdeveloped and disorganized forebrain

forebrain hypoplasia ( J:70060 )

abnormal hindbrain morphology ( J:70060 )

• at E10.5, affected heterozygotes exhibit an underdeveloped and disorganized hindbrain with a collapsed roof

cardiovascular system

hemorrhage ( J:70060 )

• some heterozygous mutant embryos display sites of hemorrhage at E12.5 and blood loss at E14.5

embryo

open neural tube ( J:70060 )

• at E10.5, a few heterozygotes exhibit an open neural tube

cellular

increased embryonic neuroepithelium apoptosis ( J:70060 )

• at E10.5, affected heterozygous mutant embryos display excessive apoptosis of neuroepithelial cells in the hindbrain region

Genotype
MGI:3842139

ht3

• Allelic Composition: Tulp3^hhkr/Tulp3⁺
• Genetic Background: involves: C3H/HeH * C57BL/6

growth/size/body

abnormal head morphology ( J:147584 )

• 6% of mice exhibit mild head misshaping or slight caudal edema

Genotype
MGI:6392330

cn4

• Allelic Composition: Tulp3^{tm1c(EUCOMM)Hmgu}/Tulp3⁺; Pkd1^tm2Ggg/Pkd1^tm2Ggg; Tg(Pax8-rtTA2S*M2)1Koes/0; Tg(tetO-cre)1Jaw/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA * SJL

renal/urinary system

polycystic kidney ( J:284006 )

• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit a severe cystic phenotype

• mice treated with Dox a P28 for 2 weeks and analyzed at 18 weeks show an intermediate cystic phenotype, with cystic index lower than conditional Pkd1 homozygotes but higher than in double Tulp3 and Pkd1 homozygotes

increased kidney weight ( J:284006 )

• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit increased kidney weight/body weight ratio due to cysts

• mice treated with Dox a P28 for 2 weeks and analyzed at 18 weeks show an intermediate kidney weight/body weight ratio, with lower ratio than conditional Pkd1 homozygotes but higher ratio than in double Tulp3 and Pkd1 homozygotes

homeostasis/metabolism

increased blood urea nitrogen level ( J:284006 )

• mice treated with Dox at P0 show increased blood urea nitrogen levels at P14

• mice treated with Dox a P28 for 2 weeks and analyzed at 18 weeks show an intermediate level of blood urea nitrogen, with lower level than conditional Pkd1 homozygotes but higher level than in double Tulp3 and Pkd1 homozygotes

growth/size/body

polycystic kidney ( J:284006 )

• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit a severe cystic phenotype

• mice treated with Dox a P28 for 2 weeks and analyzed at 18 weeks show an intermediate cystic phenotype, with cystic index lower than conditional Pkd1 homozygotes but higher than in double Tulp3 and Pkd1 homozygotes

increased kidney weight ( J:284006 )

• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit increased kidney weight/body weight ratio due to cysts

• mice treated with Dox a P28 for 2 weeks and analyzed at 18 weeks show an intermediate kidney weight/body weight ratio, with lower ratio than conditional Pkd1 homozygotes but higher ratio than in double Tulp3 and Pkd1 homozygotes

Genotype
MGI:3842144

cx5

• Allelic Composition: Gli3^Xt-J/Gli3⁺; Tulp3^hhkr/Tulp3⁺
• Genetic Background: involves: C3H/HeH * C3H/HeJ * C57BL/6

limbs/digits/tail

polydactyly ( J:147584 )

• mice exhibit a single extra digit on most limbs

Genotype
MGI:3842146

cx6

• Allelic Composition: Gli3^Xt-J/Gli3^Xt-J; Tulp3^hhkr/Tulp3⁺
• Genetic Background: involves: C3H/HeH * C3H/HeJ * C57BL/6

limbs/digits/tail

polysyndactyly ( J:147584 )

• with seven to nine digits