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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tead2+
wild type
MGI:2437362
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Tead2tm1.1Mldp/Tead2+ involves: 129X1/SvJ * C57BL/6J * FVB/N MGI:3763406
cx2
 		Tead1tm1Hssk/Tead1tm1Hssk
Tead2tm1Hssk/Tead2+
Yap1tm1Smil/Yap1+ 		either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1) MGI:3797243
cx3
 		Tead1tm1Hssk/Tead1tm1Hssk
Tead2tm1Hssk/Tead2+ 		either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1) MGI:3797239


Genotype
MGI:3763406
ht1
Allelic
Composition		 Tead2tm1.1Mldp/Tead2+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tead2tm1.1Mldp mutation (0 available); any Tead2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
exencephaly ( J:127233 )
• 6.25% to 7% of mice display exencephaly between E11.5 and E13.5




Genotype
MGI:3797243
cx2
Allelic
Composition		 Tead1tm1Hssk/Tead1tm1Hssk
Tead2tm1Hssk/Tead2+
Yap1tm1Smil/Yap1+
Genetic
Background		 either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tead1tm1Hssk mutation (1 available); any Tead1 mutation (276 available)
Tead2tm1Hssk mutation (1 available); any Tead2 mutation (34 available)
Yap1tm1Smil mutation (0 available); any Yap1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryo development ( J:131426 )
• mutants show essentially the same morphological defects as double Tead1 and Tead2 homozygotes
abnormal embryonic tissue morphology ( J:131426 )
• embryos develop a posterior-ventral protrusion
abnormal allantois morphology ( J:131426 )
• embryos develop a bulbous allantois




Genotype
MGI:3797239
cx3
Allelic
Composition		 Tead1tm1Hssk/Tead1tm1Hssk
Tead2tm1Hssk/Tead2+
Genetic
Background		 either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tead1tm1Hssk mutation (1 available); any Tead1 mutation (276 available)
Tead2tm1Hssk mutation (1 available); any Tead2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryonic growth retardation ( J:131426 )
• mutants are developmentally delayed but resemble normal E8.5 embryos

growth/size/body
embryonic growth retardation ( J:131426 )
• mutants are developmentally delayed but resemble normal E8.5 embryos




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory