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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tead1+
wild type
MGI:2437353
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Tead1tm1a(KOMP)Wtsi/Tead1+ C57BL/6N-Tead1tm1a(KOMP)Wtsi/Bay MGI:5757794
ht2
 		Tead1tm1b(KOMP)Wtsi/Tead1+ C57BL/6N-Tead1tm1b(KOMP)Wtsi/Bay MGI:5757796
cx3
 		Tead1tm1Hssk/Tead1+
Tead2tm1Hssk/Tead2tm1Hssk
Yap1tm1Smil/Yap1+ 		either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1) MGI:3797240
cx4
 		Tead1tm1Hssk/Tead1+
Tead2tm1Hssk/Tead2tm1Hssk 		either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1) MGI:3797238


Genotype
MGI:5757794
ht1
Allelic
Composition		 Tead1tm1a(KOMP)Wtsi/Tead1+
Genetic
Background		 C57BL/6N-Tead1tm1a(KOMP)Wtsi/Bay
Cell Lines EPD0207_2_C09
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tead1tm1a(KOMP)Wtsi mutation (1 available); any Tead1 mutation (276 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye




Genotype
MGI:5757796
ht2
Allelic
Composition		 Tead1tm1b(KOMP)Wtsi/Tead1+
Genetic
Background		 C57BL/6N-Tead1tm1b(KOMP)Wtsi/Bay
Cell Lines EPD0207_2_C09
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tead1tm1b(KOMP)Wtsi mutation (0 available); any Tead1 mutation (276 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue

cardiovascular system

craniofacial

growth/size/body
increased heart weight ( J:211773 )
IMPC - BCM
abnormal tooth morphology ( J:211773 )
IMPC - BCM

homeostasis/metabolism

nervous system

skeleton

vision/eye




Genotype
MGI:3797240
cx3
Allelic
Composition		 Tead1tm1Hssk/Tead1+
Tead2tm1Hssk/Tead2tm1Hssk
Yap1tm1Smil/Yap1+
Genetic
Background		 either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tead1tm1Hssk mutation (1 available); any Tead1 mutation (276 available)
Tead2tm1Hssk mutation (1 available); any Tead2 mutation (34 available)
Yap1tm1Smil mutation (0 available); any Yap1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal developmental patterning ( J:131426 )
• mutants exhibit smaller posterior tissues
abnormal embryo turning ( J:131426 )
• defective embryonic turning




Genotype
MGI:3797238
cx4
Allelic
Composition		 Tead1tm1Hssk/Tead1+
Tead2tm1Hssk/Tead2tm1Hssk
Genetic
Background		 either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tead1tm1Hssk mutation (1 available); any Tead1 mutation (276 available)
Tead2tm1Hssk mutation (1 available); any Tead2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
incomplete rostral neuropore closure ( J:131426 )
• half of the mutants show an anterior neural tube closure defect or exencephaly between E9.5 and E15.5
exencephaly ( J:131426 )
• half of the mutants show an anterior neural tube closure defect or exencephaly between E9.5 and E15.5

embryo
incomplete rostral neuropore closure ( J:131426 )
• half of the mutants show an anterior neural tube closure defect or exencephaly between E9.5 and E15.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory