Analysis Tools|
Allele Symbol Allele Name Allele ID |
Enpp1+ wild type MGI:2437231 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• on a normal diet nephrocalcinosis is not found, but when fed a high phosphorus/low calcium diet heterozygotes show increased mineralization in the kidneys
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mineralization of the medulary tubules and arcuate and renal arteries is found in heterozygotes, not just homozygotes, when fed a diet rich in phosphorus and low in magnesium
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• when fed a diet rich in phosphorus and low in magnesium
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• heterozygotes have reduced levels of plasma PPi, approximately 60% of normal levels
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• when fed a diet rich in phosphorus and low in magnesium
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• calcification of the fibrous capsule surrounding the muzzle vibrissae occurs at 15 weeks of age
• calcification is more severe than with the Abcc6tm1Jfk null allele alone and slightly less severe than in double null mutant
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/08/2026 MGI 6.24 |
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