Phenotypes associated with this allele

• Allele Symbol: Vezf1⁺
• Allele Name: wild type
• Allele ID: MGI:2437137
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Vezf1^tm1Stmn/Vezf1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3583445
ht2	Vezf1^tm1Stmn/Vezf1^+	B6.129-Vezf1^tm1Stmn	MGI:3583443

Genotype
MGI:3583445

ht1

• Allelic Composition: Vezf1^tm1Stmn/Vezf1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:99326 )

• Background Sensitivity: offspring recovered at a ratio of 41% heterozygote to 59% wildtype

cardiovascular system

abnormal blood vessel morphology ( J:99326 )

• Background Sensitivity: approximately 10% of embryos display vascular abnormalities

Genotype
MGI:3583443

ht2

• Allelic Composition: Vezf1^tm1Stmn/Vezf1⁺
• Genetic Background: B6.129-Vezf1^tm1Stmn

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:99326 )

• Background Sensitivity: hemorrhaging embryos die before E14.5

• Background Sensitivity: non-hemorrhaging embryos develop into viable, fertile adults with no apparent abnormalities

cardiovascular system

abnormal blood vessel morphology ( J:99326 )

• Background Sensitivity: hypervascularization detected in close association with the jugular sac

• Background Sensitivity: blood filled, enlarged, irregularly shaped, and anastomosing vessels in the jugular region

• Background Sensitivity: increased overall vessel number (50%) and total vessel area (130%) in the mid-back region

• Background Sensitivity: vascular lesions with erythrocytes leaking out into the mesenchymal tissue observed between E12.5 and E13.5

internal hemorrhage ( J:99326 )

• Background Sensitivity: beginning at E12.5, about 20% of embryos display localized edema and hemorrhaging in the back and jugular region

• Background Sensitivity: by E13.5 embryos appear bloated and displayed massive edema and bleeding

• Background Sensitivity: parasagittal embryo sections show severe edema with masses of loose connective tissue and mesenchymal cells separated by interstitial fluid and subcutaneous bleeding in the back and neck region

• Background Sensitivity: hemorrhaging embryos not detected past E14.5

immune system

abnormal lymphatic vessel morphology ( J:99326 )

• Background Sensitivity: lymphatic hypervascularization in the jugular region of embryos

embryo

increased embryo size ( J:99326 )

• Background Sensitivity: embryos appear bloated at E12.5

growth/size/body

increased embryo size ( J:99326 )

• Background Sensitivity: embryos appear bloated at E12.5