Phenotypes associated with this allele

• Allele Symbol: Sptbn2⁺
• Allele Name: wild type
• Allele ID: MGI:2437126
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Sptbn2^tm1Mjac/Sptbn2^+	involves: 129P2/OlaHsd	MGI:5426692
ht2	Sptbn2^Gt(XK442)Byg/Sptbn2^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:5300033

Genotype
MGI:5426692

ht1

• Allelic Composition: Sptbn2^tm1Mjac/Sptbn2⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:163169 )

N • heterozygotes do not show signs of ataxia, with no differences in base width or stride lengths and in motor performance on a stationary rod, elevated beam or a rotating rod task

nervous system

nervous system phenotype ( J:163169 )

N • heterozygotes exhibit a normal cerebellum at 2 years of age and do not show signs of cerebellar degeneration or changes in Purkinje cell morphology

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	spinocerebellar ataxia 5	DOID:0050882	OMIM:600224	J:163169

Genotype
MGI:5300033

ht2

• Allelic Composition: Sptbn2^Gt(XK442)Byg/Sptbn2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

behavior/neurological

impaired coordination ( J:158494 )

• slight motor impairment is observed in the hanging wire test