Phenotypes associated with this allele

• Allele Symbol: Hipk1⁺
• Allele Name: wild type
• Allele ID: MGI:2437067
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Hipk1^tm1Hko/Hipk1^+ Hipk2^tm1Hko/Hipk2^tm1Hko	involves: C57BL/6	MGI:3625000

Genotype
MGI:3625000

cx1

• Allelic Composition: Hipk1^tm1Hko/Hipk1⁺; Hipk2^tm1Hko/Hipk2^tm1Hko
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:106931 )

• about half of the mutants are lost during gestation, compared to the predicted number

cellular

decreased cellular sensitivity to ultraviolet irradiation induced cell death ( J:106931 )

• embryonic fibroblasts from mutant mice are more resistant to UV radiation compared to single Hipk1 or Hipk2-null mice

• decreased numbers of apoptotic cells induced by UV irradiation are observed in MEFs compared to wild-type

nervous system

abnormal neural tube morphology ( J:106931 )

• neural tube defects occur more frequently in female compound mutants

embryo

abnormal neural tube morphology ( J:106931 )

• neural tube defects occur more frequently in female compound mutants