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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfsf11+
wild type
MGI:2437058
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Tnfsf11tm1.2Htaka/Tnfsf11+ B6.Cg-Tnfsf11tm1.2Htaka MGI:5297088
ht2
 		Tnfsf11tm1Ywc/Tnfsf11+ involves: 129P2/OlaHsd MGI:3800992
cx3
 		Tg(Bglap2-TAg)1Rkho/0
Tnfsf11tm1Pngr/Tnfsf11+ 		involves: 129P2/OlaHsd * FVB/N MGI:5796172


Genotype
MGI:5297088
ht1
Allelic
Composition		 Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic
Background		 B6.Cg-Tnfsf11tm1.2Htaka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf11tm1.2Htaka mutation (0 available); any Tnfsf11 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal trabecular bone morphology ( J:177557 )
• trabecular separation is decreased compared to in wild-type mice

immune system

hematopoietic system




Genotype
MGI:3800992
ht2
Allelic
Composition		 Tnfsf11tm1Ywc/Tnfsf11+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf11tm1Ywc mutation (0 available); any Tnfsf11 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
absent peripheral lymph nodes ( J:65888 )
• in some mice, peripheral lymph nodes are absent




Genotype
MGI:5796172
cx3
Allelic
Composition		 Tg(Bglap2-TAg)1Rkho/0
Tnfsf11tm1Pngr/Tnfsf11+
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Bglap2-TAg)1Rkho mutation (0 available)
Tnfsf11tm1Pngr mutation (0 available); any Tnfsf11 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased osteosarcoma incidence ( J:234128 )
• mice exhibit the same tumor incidence, burden and survival as single Tg(Bglap2-TAg)1Rkho hemizygous mice

skeleton
increased osteosarcoma incidence ( J:234128 )
• mice exhibit the same tumor incidence, burden and survival as single Tg(Bglap2-TAg)1Rkho hemizygous mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory