Phenotypes associated with this allele

• Allele Symbol: Kdm5a⁺
• Allele Name: wild type
• Allele ID: MGI:2437045
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Kdm5a^tm1.1Kael/Kdm5a^+ Rb1^tm1Tyj/Rb1^+	involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N	MGI:5296663
cx2	Kdm5a^tm1.1Kael/Kdm5a^+ Rb1^tm1Tyj/Rb1^tm1Tyj	involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N	MGI:5296665

Genotype
MGI:5296663

cx1

• Allelic Composition: Kdm5a^tm1.1Kael/Kdm5a⁺; Rb1^tm1Tyj/Rb1⁺
• Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pituitary gland tumor incidence ( J:175625 )

• in 15 of 18 mice; 9 of 12 with intermediate lobe origins, 1 in 12 anterior lobe origins, and 2 of 12 intermediate and anterior lobe origins

increased thyroid tumor incidence ( J:175625 )

• in 16 of 18 mice

endocrine/exocrine glands

increased pituitary gland tumor incidence ( J:175625 )

• in 15 of 18 mice; 9 of 12 with intermediate lobe origins, 1 in 12 anterior lobe origins, and 2 of 12 intermediate and anterior lobe origins

increased thyroid tumor incidence ( J:175625 )

• in 16 of 18 mice

nervous system

increased pituitary gland tumor incidence ( J:175625 )

• in 15 of 18 mice; 9 of 12 with intermediate lobe origins, 1 in 12 anterior lobe origins, and 2 of 12 intermediate and anterior lobe origins

Genotype
MGI:5296665

cx2

• Allelic Composition: Kdm5a^tm1.1Kael/Kdm5a⁺; Rb1^tm1Tyj/Rb1^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N

mortality/aging

embryonic lethality, complete penetrance ( J:175625 )

cellular

increased fibroblast proliferation ( J:175625 )

• in mouse embryonic fibroblasts