Analysis Tools|
Allele Symbol Allele Name Allele ID |
Hcn4+ wild type MGI:2436661 |
||||||||||||||||||||
| Summary |
4 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• embryo heart rate fails to increase between E9.5 and E11.5 as it does in controls
• embryo heart rate is slower than in controls
• adult heart rate is similar to that of controls
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• thin and sparse layer in the absence of doxycycline
• fewer glomeruli in the olfactory bulb in the absence of doxycycline
• loss of glomeruli in the dorsal region in the absence of doxycycline
• however, doxycycline treatment from E1 through P28 rescues the number of glomeruli and loss of glomeruli in the dorsal region
|
|
• shorter along the rostro-caudal axis at 4 weeks in the absence of doxycycline
• smaller area around the eminence of the bulb over the transition to the olfactory tract in the absence of doxycycline
|
|
• in the absence of doxycycline, single-unit spontaneous firing rate in olfactory receptor neurons is increased compared with control mice
• however, doxycycline-treatment restores normal firing rate
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• tamoxifen treated mice exhibit normal modulation of heart rate
|
|
• tamoxifen treated mice are indistinguishable from wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• approximately 20% of mice die suddenly with no ante-mortem indication of illness within 60 days after high dose tamoxifen treatment
|
|
• ablation of sinoatrial node cells following tamoxifen treatment that varies depending on tamoxifen dose
|
|
• tamoxifen induced ablation of sinoatrial node cells is accompanied by a destructive fibrosis of nodal tissue
|
|
• following 5 days of tamoxifen treatment show alternating periods of slow and fast frequencies in R-R tachograms
• alterations of long electrical standstills (sinus pauses) and intermittent rapid atrial activity following tamoxifen treatment
• following 5 days of tamoxifen treatment absolute value of the maximally (isoprenaline) stimulated heart rate remained low
|
|
• following 5 days of high or low dose tamoxifen treatment heart rate falls by about 40 - 50% or 12%, respectively
|
|
• variety of cardiac rhythm disturbances; including sino-atrial arrhythmia, sino-atrial pause and to a minor extent supraventricular or ventricular tachycardia, following tamoxifen treatment
|
|
• complete heart block some weeks after tamoxifen treatment
|
|
• following tamoxifen treatment
• progressive prolongation of the P-R interval tends to result in complete isolated contraction of atria and ventricles with high dose tamoxifen treatment
|
|
• ablation of sinoatrial node cells following tamoxifen treatment that varies depending on tamoxifen dose
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| sick sinus syndrome | DOID:13884 |
OMIM:163800 OMIM:608567 |
J:186021 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 01/13/2026 MGI 6.24 |
|
|
|
||
