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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdkl5+
wild type
MGI:2436632
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Cdkl5tm1.2Cogr/Cdkl5+ involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J MGI:5574072
cn2
 		Cdkl5tm1.1Cogr/Cdkl5+
Tg(Emx1-cre)#Ito/0 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * C57BL/6J MGI:5574070
cx3
 		Cdkl5tm1.2Cogr/Cdkl5+
Tg(Thy1-YFP)#Jrs/0 		involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA MGI:5574077


Genotype
MGI:5574072
ht1
Allelic
Composition		 Cdkl5tm1.2Cogr/Cdkl5+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5tm1.2Cogr mutation (2 available); any Cdkl5 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased locomotor activity ( J:209635 )
• intermediate in the home cage
• however, activity in a novel open arena is normal

vision/eye
abnormal visual evoked potential ( J:209635 )
• decreased amplitude, but not latency, of the first positive wave




Genotype
MGI:5574070
cn2
Allelic
Composition		 Cdkl5tm1.1Cogr/Cdkl5+
Tg(Emx1-cre)#Ito/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5tm1.1Cogr mutation (1 available); any Cdkl5 mutation (20 available)
Tg(Emx1-cre)#Ito mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:209635 )
N
• mice exhibit normal activity levels and a trend for decreased head tracking
limb grasping ( J:209635 )
• in some mice




Genotype
MGI:5574077
cx3
Allelic
Composition		 Cdkl5tm1.2Cogr/Cdkl5+
Tg(Thy1-YFP)#Jrs/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5tm1.2Cogr mutation (2 available); any Cdkl5 mutation (20 available)
Tg(Thy1-YFP)#Jrs mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
thin cerebral cortex ( J:209635 )
• intermediate
abnormal dendrite morphology ( J:209635 )
• intermediate reduction in total length of apical dendritic arbors of cortical and hippocampal pyramidal neurons with bimodal distribution




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory