Phenotypes associated with this allele
Allelic Composition |
Fhittm1Tko/Fhit+
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Genetic Background |
involves: 129X1/SvJ |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fhittm1Tko mutation
(0 available);
any
Fhit mutation
(22 available)
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neoplasm
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• occurred in 2 out of 90 heterozygous mice over 12 months of age
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• in mutants older than 12 months increased incidence of B cell lymphomas (16 out of 90) and lymphocyte infiltrations (5 out of 90) are seen
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• forestomach papillomas occurred in 22 out of 90 heterozygous mice over 12 months of age
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digestive/alimentary system
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• small intestinal lesions including polyps (6 out of 90), fused villi (5 out of 90) and swollen crypts (8 out of 90) are seen
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Allelic Composition |
Fhittm1Hbn/Fhit+
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Genetic Background |
involves: 129X1/SvJ * C57BL/6 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fhittm1Hbn mutation
(0 available);
any
Fhit mutation
(22 available)
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mortality/aging
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• 26% of heterozygous mice were found dead before normal life span with evidence of widespread infections
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neoplasm
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• in untreated mice, the incidence of spontaneous tumors of various types was 53%
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• 10 weeks after NMBA treatment, all heterozygous mice exhibited tumors in various tissues, especially the gastrointestinal tract including the forestomach and squamocolumnar juction; the incidence of tumors in control mice was 25%
(J:61946)
• 78% of mice exhibit large sebaceous tumors after a single dose of NMBA, especially in the gastrointestinal tract
(J:71303)
• mutants develop preneoplastic lesions of the uterus more frequently than wild-type after multiple doses of benzol[a]pyrene (B[a]P), however develop similar levels of forestomach and lung tumors
(J:110096)
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hematopoietic system
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• granulocyte numbers are 2-6% of total blood lymphocytes; controls granulocyte numbers are 15% of total
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immune system
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• granulocyte numbers are 2-6% of total blood lymphocytes; controls granulocyte numbers are 15% of total
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• mice exhibit evidence of widespread infections and abcesses
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homeostasis/metabolism
integument
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• spontaneous alopecia areata and hair bulb cell apoptosis are greatly accelerated in mutants compared to wild-type
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