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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tlr9+
wild type
MGI:2436557
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Tlr9M2Btlr/Tlr9+ C57BL/6J-Tlr9M2Btlr MGI:3767573
ht2
 		Tlr9m4Btlr/Tlr9+ C57BL/6J-Tlr9m4Btlr MGI:3776491
ht3
 		Tlr9M5Btlr/Tlr9+ C57BL/6J-Tlr9M5Btlr MGI:3843071
ht4
 		Tlr9M7Btlr/Tlr9+ C57BL/6J-Tlr9M7Btlr MGI:4838260
ht5
 		Tlr9M9Btlr/Tlr9+ C57BL/6J-Tlr9M9Btlr MGI:5632143


Genotype
MGI:3767573
ht1
Allelic
Composition		 Tlr9M2Btlr/Tlr9+
Genetic
Background		 C57BL/6J-Tlr9M2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr9M2Btlr mutation (1 available); any Tlr9 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:128405 )
• in response to CpG ODN, macrophages from mice heterozygous for the Cpg2 mutation produce an amount of TNF-alpha intermediate between homozygous mutant and wild-type levels

hematopoietic system
abnormal macrophage physiology ( J:128405 )
• in response to CpG ODN, macrophages from mice heterozygous for the Cpg2 mutation produce an amount of TNF-alpha intermediate between homozygous mutant and wild-type levels




Genotype
MGI:3776491
ht2
Allelic
Composition		 Tlr9m4Btlr/Tlr9+
Genetic
Background		 C57BL/6J-Tlr9m4Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr9m4Btlr mutation (1 available); any Tlr9 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell proliferation ( J:132489 )
• naive peripheral B lymphocytes from heterozygous mutant mice fail to proliferate in vitro in response to stimulation with CPG ODN
abnormal macrophage physiology ( J:132489 )
• peritoneal macrophages from mice heterozygous for this mutation secrete little or no tumor necrosis factor- (TNF-) alpha in response to oligonucleotides containing unmethylated CpG motifs (CPG ODNs)
• responses of heterozygous mutant peritoneal macrophages to all TLR ligands except CPG ODNs are similar to those of wild-type macrophages
abnormal plasmacytoid dendritic cell physiology ( J:132489 )
• plasmacytoid dendritic cells (pDCs) from heterozygous mutant mice do not produce interferon alpha in response to mouse cytomegalovirus (MCMV), herpes simplex virus type I (HSV-1) or herpes simplex virus type 2 (HSV-2)

hematopoietic system
decreased B cell proliferation ( J:132489 )
• naive peripheral B lymphocytes from heterozygous mutant mice fail to proliferate in vitro in response to stimulation with CPG ODN
abnormal macrophage physiology ( J:132489 )
• peritoneal macrophages from mice heterozygous for this mutation secrete little or no tumor necrosis factor- (TNF-) alpha in response to oligonucleotides containing unmethylated CpG motifs (CPG ODNs)
• responses of heterozygous mutant peritoneal macrophages to all TLR ligands except CPG ODNs are similar to those of wild-type macrophages

cellular
decreased B cell proliferation ( J:132489 )
• naive peripheral B lymphocytes from heterozygous mutant mice fail to proliferate in vitro in response to stimulation with CPG ODN




Genotype
MGI:3843071
ht3
Allelic
Composition		 Tlr9M5Btlr/Tlr9+
Genetic
Background		 C57BL/6J-Tlr9M5Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr9M5Btlr mutation (1 available); any Tlr9 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interferon-alpha secretion ( J:147856 )
• the index mouse was identified in a screen of G1 progeny of an ENU mutagenized mouse for reduced type I interferon (IFN) response to in vivo challenge with unmethylated CpG oligonucleotides
decreased interferon-beta secretion ( J:147856 )
• the index mouse was identified in a screen of G1 progeny of an ENU mutagenized mouse for reduced type I interferon (IFN) response to in vivo challenge with unmethylated CpG oligonucleotides




Genotype
MGI:4838260
ht4
Allelic
Composition		 Tlr9M7Btlr/Tlr9+
Genetic
Background		 C57BL/6J-Tlr9M7Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr9M7Btlr mutation (1 available); any Tlr9 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:165701 )
• upon stimulation with oligodeoxynucleotides containing CpG motifs (CpG ODNs), a Toll-like receptor 9 ligand, peritoneal macrophages from mice heterozygous for this mutation produce levels of tumor necrosis factor (TNF-) alpha intermediate between those of wild-type and homozygous mutant mice




Genotype
MGI:5632143
ht5
Allelic
Composition		 Tlr9M9Btlr/Tlr9+
Genetic
Background		 C57BL/6J-Tlr9M9Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr9M9Btlr mutation (0 available); any Tlr9 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:220063 )
• mice with this mutation exhibit decreased TNFalpha secretion in response to the TLR9 ligand CpG oligodeoxynucleotide; secretion in heterozygous mutant mice is intermediate between that of wild-type and homozygous mutants.




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory