About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cys1+
wild type
MGI:2436530
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Cys1cpk/Cys1+ B6(Cg)-Cys1cpk/J MGI:3583533
ht2
Cys1cpk/Cys1+ C.B6(Cg)-Cys1cpk MGI:3583563
ht3
Cys1cpk/Cys1+ involves: C57BL/6J * CD-1 MGI:3583534


Genotype
MGI:3583533
ht1
Allelic
Composition
Cys1cpk/Cys1+
Genetic
Background
B6(Cg)-Cys1cpk/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cys1cpk mutation (1 available); any Cys1 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• the perilymphatic side of Reissner's membrane is transparent but the endolymphatic side is normal
• the organ of Corti is absent from the first cochlear turn but present in the second cochlear turn
• in the second cochlear turn the inner and outer hair cells are normal but debris is seen in Nuel's space and the outer pillar cells
• in the upper portion of the first turn of the cochlea outer hair cells are absent
• in the upper portion of the first turn of the cochlea, vesicle formation is seen in the inner hair cells
• some inner pillar cells show a cystic formation at the base of the cell
• hearing is impaired with auditory evoked potential indicating some hearing loss at 90 db

nervous system
• in the upper portion of the first turn of the cochlea outer hair cells are absent
• in the upper portion of the first turn of the cochlea, vesicle formation is seen in the inner hair cells
• few spiral ganglia are seen in the first cochlear turn




Genotype
MGI:3583563
ht2
Allelic
Composition
Cys1cpk/Cys1+
Genetic
Background
C.B6(Cg)-Cys1cpk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cys1cpk mutation (1 available); any Cys1 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• massive hepatic biliary ductal cysts are seen in 1 year old heterozygotes
• associated with liver cysts

growth/size/body
• massive hepatic biliary ductal cysts are seen in 1 year old heterozygotes




Genotype
MGI:3583534
ht3
Allelic
Composition
Cys1cpk/Cys1+
Genetic
Background
involves: C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cys1cpk mutation (1 available); any Cys1 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• proximal tubular cysts seen in 1 year old heterozygotes

liver/biliary system
• heptatic cysts lined with biliary epithelium are seen in 1 year old heterozygotes
• seen in 1 year old heterozygotes, associated with hepatic cysts

growth/size/body
• proximal tubular cysts seen in 1 year old heterozygotes
• heptatic cysts lined with biliary epithelium are seen in 1 year old heterozygotes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
01/13/2026
MGI 6.24
The Jackson Laboratory