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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ndst1+
wild type
MGI:2436259
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ndst1tm1.1Grob/Ndst1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4421703
cx2
 		Ndst1tm1.1Grob/Ndst1+
Shhtm1Chg/Shh+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3589447


Genotype
MGI:4421703
ht1
Allelic
Composition		 Ndst1tm1.1Grob/Ndst1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndst1tm1.1Grob mutation (0 available); any Ndst1 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:155870 )
N
• no evidence for anemia or thrombocytopenia




Genotype
MGI:3589447
cx2
Allelic
Composition		 Ndst1tm1.1Grob/Ndst1+
Shhtm1Chg/Shh+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndst1tm1.1Grob mutation (0 available); any Ndst1 mutation (47 available)
Shhtm1Chg mutation (2 available); any Shh mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
mandible hypoplasia ( J:100425 )
• at E15.5, 4 of 8 mutants display hyploplastic lower jaws
frontonasal prominence hypoplasia ( J:100425 )
• at E15.5, 4 of 8 mutants display hypoplastic frontonasal or maxillary processes
abnormal maxillary prominence morphology ( J:100425 )
• at E15.5, 4 of 8 mutants display hypoplastic frontonasal or maxillary processes
absent tongue ( J:100425 )
• at E15.5, 4 of 8 mutants lack a tongue
absent olfactory epithelium ( J:100425 )
• at E15.5, 4 of 8 mutants lack olfactory epithelium
small snout ( J:100425 )
• surviving mutants generally have a smaller snout

vision/eye
aphakia ( J:100425 )
• at E15.5, 4 of 8 mutants display absent or hypoplastic eye lenses
abnormal eye development ( J:100425 )
• at E15.5, 4 of 8 mutants display severe eye developmental defects
microphthalmia ( J:100425 )
• surviving mutants generally have smaller eyes

digestive/alimentary system
absent tongue ( J:100425 )
• at E15.5, 4 of 8 mutants lack a tongue

taste/olfaction
absent olfactory epithelium ( J:100425 )
• at E15.5, 4 of 8 mutants lack olfactory epithelium

skeleton
mandible hypoplasia ( J:100425 )
• at E15.5, 4 of 8 mutants display hyploplastic lower jaws

respiratory system
absent olfactory epithelium ( J:100425 )
• at E15.5, 4 of 8 mutants lack olfactory epithelium

growth/size/body
mandible hypoplasia ( J:100425 )
• at E15.5, 4 of 8 mutants display hyploplastic lower jaws
absent tongue ( J:100425 )
• at E15.5, 4 of 8 mutants lack a tongue
absent olfactory epithelium ( J:100425 )
• at E15.5, 4 of 8 mutants lack olfactory epithelium
small snout ( J:100425 )
• surviving mutants generally have a smaller snout




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory