Phenotypes associated with this allele

• Allele Symbol: Snrk⁺
• Allele Name: wild type
• Allele ID: MGI:2436131
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Snrk^tm1Hxu/Snrk^+	C57BL/6-Snrk^tm1Hxu	MGI:6284776
cn2	Snrk^tm2Rra/Snrk^+ Tg(Myh6-cre)2182Mds/0	involves: C57BL/6J * FVB/N	MGI:5792711

Genotype
MGI:6284776

ht1

• Allelic Composition: Snrk^tm1Hxu/Snrk⁺
• Genetic Background: C57BL/6-Snrk^tm1Hxu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased subcutaneous adipose tissue amount ( J:257980 )

• white adipose tissue (WAT) is decreased by 50% in subcutaneous tissue

decreased white adipose tissue amount ( J:257980 )

• white adipose tissue (WAT) is decreased by 40% in epididymal tissue and 50% in subcutaneous tissue

abnormal brown fat cell morphology ( J:257980 )

• mitochondria density in BAT is decreased and has occasional ruptures of mitochondrial cristae

decreased brown fat cell size ( J:257980 )

• brown adipose tissue (BAT) mass is decreased by 33% and have with less lipid accumulation

abnormal white fat cell morphology ( J:257980 )

• crown-like structure found in WAT

growth/size/body

slow postnatal weight gain ( J:257980 )

• body weight in males is similar to wild-type at 4 weeks, but decreases by 22 weeks

homeostasis/metabolism

increased circulating glucose level ( J:257980 )

• on high fat diet, mice exhibit higher fasting blood glucose levels, however, there are no differences in body or fat pad weight

decreased triglyceride level ( J:257980 )

• triglyceride contents of epididymal and subcutaneous WAT is decreased

integument

decreased subcutaneous adipose tissue amount ( J:257980 )

• white adipose tissue (WAT) is decreased by 50% in subcutaneous tissue

Genotype
MGI:5792711

cn2

• Allelic Composition: Snrk^tm2Rra/Snrk⁺; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: C57BL/6J * FVB/N

mortality/aging

premature death ( J:218247 )

• mice die shortly after one year of age