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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Degs1+
wild type
MGI:2436099
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Degs1em1(IMPC)Mbp/Degs1+ C57BL/6NCrl-Degs1em1(IMPC)Mbp/MbpMmucd MGI:7551092
ht2
Degs1Gt(OST368559)Lex/Degs1+ involves: 129S5/SvEvBrd MGI:5527442


Genotype
MGI:7551092
ht1
Allelic
Composition
Degs1em1(IMPC)Mbp/Degs1+
Genetic
Background
C57BL/6NCrl-Degs1em1(IMPC)Mbp/MbpMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Degs1em1(IMPC)Mbp mutation (1 available); any Degs1 mutation (24 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye




Genotype
MGI:5527442
ht2
Allelic
Composition
Degs1Gt(OST368559)Lex/Degs1+
Genetic
Background
involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Degs1Gt(OST368559)Lex mutation (1 available); any Degs1 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• in untreated and dexamethasone-treated mice
• reduced ratio of active ceramide to inactive dihydroceramide compared with wild-type mice

muscle
• increased in insulin-treated muscles in the presence of palmitate
• however, basal uptake and insulin-stimulated uptake in the presence of linoleate are normal

cellular
• increased in insulin-treated muscles in the presence of palmitate
• however, basal uptake and insulin-stimulated uptake in the presence of linoleate are normal





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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory