Phenotypes associated with this allele

• Allele Symbol: Mbtps1⁺
• Allele Name: wild type
• Allele ID: MGI:2435958
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mbtps1^Gt(PST115)Byg/Mbtps1^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3837829
cn2	Mbtps1^tm1Jdh/Mbtps1^+ Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0	involves: 129S6/SvEvTac * C57BL/6 * CD-1	MGI:7281135

Genotype
MGI:3837829

ht1

• Allelic Composition: Mbtps1^{Gt(PST115)Byg}/Mbtps1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:146454 )

• only half the expected number of pups with this genotype are born

Genotype
MGI:7281135

cn2

• Allelic Composition: Mbtps1^tm1Jdh/Mbtps1⁺; Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

growth/size/body

decreased body size ( J:258274 )

• heterozygous mice are smaller than wild-type or recombinase expressing controls but larger than homozygous mice

skeleton

abnormal appendicular skeleton morphology ( J:258274 )

• smaller appendicular elements, intermediate to homozygous mice

abnormal axial skeleton morphology ( J:258274 )

• smaller axial elements, intermediate to homozygous mice

abnormal compact bone thickness ( J:258274 )

• mid-diaphyseal cortical bone is smaller in width but not reduced in thickness

abnormal bone ossification ( J:258274 )

• osteogenic capacity of bone marrow stem cells is absent in vitro