Phenotypes associated with this allele

• Allele Symbol: Stat3⁺
• Allele Name: wild type
• Allele ID: MGI:2435788
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Stat3^tm1Xyfu/Stat3^+	involves: 129S1/Sv * C57BL/6	MGI:3768556
cn2	Stat3^tm1Vpo/Stat3^+ Tg(Myh6-cre)2182Mds/0	involves: 129P2/OlaHsd * FVB/N	MGI:5906909
cn3	Stat3^tm1Xyfu/Stat3^+ Tg(Myh6-cre)2182Mds/0	involves: 129S1/Sv * FVB/N	MGI:4879021
cx4	Il6st^tm1Ern/Il6st^tm1Ern Stat3^tm1Aki/Stat3^+	involves: 129P2/OlaHsd * 129S1/Sv	MGI:3837309

Genotype
MGI:3768556

ht1

• Allelic Composition: Stat3^tm1Xyfu/Stat3⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:128719 )

• mortality during the first 12 hours following 70% hepatectomy is 5.5%

Genotype
MGI:5906909

cn2

• Allelic Composition: Stat3^tm1Vpo/Stat3⁺; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

mortality/aging

pregnancy-related premature death ( J:141591 )

• postpartum cardiomyopathy-related death is seen after 3-4 deliveries

cardiovascular system

cardiomyopathy ( J:141591 )

• females develop postpartum cardiomyopathy

congestive heart failure ( J:141591 )

• after 4 pregnancies, the majority of females show signs of overt heart failure such as generalized edema and labored breathing

homeostasis/metabolism

generalized edema ( J:141591 )

• females exhibit generalized edema after 4 pregnancies

muscle

cardiomyopathy ( J:141591 )

• females develop postpartum cardiomyopathy

Genotype
MGI:4879021

cn3

• Allelic Composition: Stat3^tm1Xyfu/Stat3⁺; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S1/Sv * FVB/N

immune system

increased tumor necrosis factor secretion ( J:86400 )

• in the cardiac myocytes of LPS-treated mice

increased susceptibility to endotoxin shock ( J:86400 )

• LPS-treated mice exhibit increased TNF-alpha levels in cardiac myocytes compared with similarly treated wild-type mice although not as severely as in homozygous mice

cardiovascular system

cardiac fibrosis ( J:86400 )

• severe at 9 months

Genotype
MGI:3837309

cx4

• Allelic Composition: Il6st^tm1Ern/Il6st^tm1Ern; Stat3^tm1Aki/Stat3⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

mortality/aging

mortality/aging ( J:100160 )

N • improved survival

immune system

immune system phenotype ( J:100160 , J:139226 , J:142883 )

N • splenomegaly fails to develop (J:100160)

N • neutrophil infiltration of the peritoneal cavity and subsequent clearance in induced inflammation normal (J:139226)

N • response to arthritis induced with methylated serum albumin is comparable to control animals (J:142883)

decreased circulating interleukin-6 level ( J:168781 )

• in LPS-treated mice compared with similarly treated Il6st^tm1Ern homozygotes

decreased susceptibility to endotoxin shock ( J:168781 )

• compared with LPS-treated Il6st^tm1Ern homozygotes

digestive/alimentary system

digestive/alimentary phenotype ( J:100160 )

N • stomach size remains normal

neoplasm

neoplasm ( J:100160 )

N • numbers of gastric adenomas is reduced

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:168781 )

• in LPS-treated mice compared with similarly treated Il6st^tm1Ern homozygotes