Phenotypes associated with this allele

• Allele Symbol: B2m⁺
• Allele Name: wild type
• Allele ID: MGI:2435732
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	B2m^tm1b(EUCOMM)Wtsi/B2m^+	C57BL/6N-B2m^tm1b(EUCOMM)Wtsi/Tcp	MGI:6288352
ht2	B2m^tm1Unc/B2m^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3762580

Genotype
MGI:6288352

ht1

• Allelic Composition: B2m^{tm1b(EUCOMM)Wtsi}/B2m⁺
• Genetic Background: C57BL/6N-B2m^{tm1b(EUCOMM)Wtsi}/Tcp
• Cell Lines: EPD0620_2_B08

Data Sources

IMPC Data for B2m

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating phosphate level ( J:211773 )

♀

IMPC - UCD

integument

abnormal skin morphology ( J:211773 )

♀

IMPC - UCD

nervous system

small superior vagus ganglion ( J:211773 )

♀

IMPC - UCD

reproductive system

hydrometra ( J:211773 )

♀

IMPC - UCD

Genotype
MGI:3762580

ht2

• Allelic Composition: B2m^tm1Unc/B2m⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

immune system

decreased CD8-positive, alpha-beta T cell number ( J:64451 )

• numbers of CD8+CD4- T cells from the thymus of five week old mice are reduced in comparison to control (4.9% vs. 6.7%), however, in peripheral lymphoid tissues numbers of CD8+CD4- T cells do not differ from control

decreased level of surface class I molecules ( J:64451 )

• surface expression of class I molecules in cells from lymph nodes are reduced in comparison to control

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:64451 )

• numbers of CD8+CD4- T cells from the thymus of five week old mice are reduced in comparison to control (4.9% vs. 6.7%), however, in peripheral lymphoid tissues numbers of CD8+CD4- T cells do not differ from control