All Phenotypes Drd3<+> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Drd3^tm1Dac/Drd3⁺	involves: 129S4/SvJae * C57BL/6	MGI:3614421
ht2	Drd3^tm1Dac/Drd3⁺	involves: 129S4/SvJae * C57BL/6J	MGI:4839943
cx3	Drd2^tm1Schm/Drd2^tm1Schm Drd3^tm1Schm/Drd3⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3623127

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased exploration in new environment ( J:32128 )

• heterozygotes exhibit increased exploratory behavior in the open field, with a degree of hyperactivity comparable to than of homozygotes during the last 11 min of a 15-min test

decreased grooming behavior ( J:32128 )

• heterozygotes tend to show reduced grooming behavior with a delayed onset; however, these differences are not statistically significant relative to wild-type grooming behavior

abnormal locomotor activation ( J:96229 )

• during the first part of the test (increased early and decreased late) unlike wild-type mice

hyperactivity ( J:96229 , J:32128 )

• during the first part of the test (J:96229)

• in the open field test, heterozygotes display hyperactivity, as shown by a 38% increase in locomotor activity (crossings) relative to wild-type mice (J:32128)

increased vertical activity ( J:96229 , J:32128 )

• during the first part of the test (J:96229)

• in the open field test, heterozygotes display 77% more rearing episodes than wild-type mice (J:32128)

cardiovascular system

increased systemic arterial diastolic blood pressure ( J:115136 )

• after anesthesia with pentobarbital

increased systemic arterial systolic blood pressure ( J:115136 )

• after anesthesia with pentobarbital

homeostasis/metabolism

increased renin activity ( J:115136 )

Allelic Composition	Drd3^tm1Dac/Drd3⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd3^tm1Dac mutation (2 available); any Drd3 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased anxiety-related response ( J:44685 )

• mice exhibit moderately more time in the center of the open field and with the open arms of an elevated plus maze compared with wild-type mice

Allelic Composition	Drd2^tm1Schm/Drd2^tm1Schm Drd3^tm1Schm/Drd3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2^tm1Schm mutation (0 available); any Drd2 mutation (70 available)
Drd3^tm1Schm mutation (0 available); any Drd3 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor behavior ( J:79483 )

• male mice 70 days old show decreased locomotor activity and distance traveled compared to wild-type but these parameters are still significantly greater than double homozygotes

homeostasis/metabolism

abnormal dopamine level ( J:79483 )

• although steady state dopamine levels do not differ significantly from wild-type, there is a significant increase in dopamine metabolites (HVA and DOPAC) in male mutants

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