Phenotypes associated with this allele

• Allele Symbol: Drd2⁺
• Allele Name: wild type
• Allele ID: MGI:2435724
• Summary: 8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	\Drd2^tm1Low/\Drd2^+	129S/Sv-Drd2^tm1Low	MGI:4429670
ht2	\Drd2^tm1(IL2RA)Koba/\Drd2^+	B6.129P2-Drd2^tm1(IL2RA)Koba	MGI:3719696
ht3	\Drd2^tm1Low/\Drd2^+	B6.129S2-Drd2^tm1Low	MGI:4429668
ht4	\Drd2^tm1Yyw/\Drd2^+	B6.129S4-Drd2^tm1Yyw	MGI:3576287
ht5	\Drd2^tm1Ebo/\Drd2^+	involves: 129S2/SvPas * C57BL/6	MGI:3615305
ht6	\Drd2^tm1Low/\Drd2^+	involves: 129S2/SvPas * C57BL/6J	MGI:4429666
cx7	\Drd2^tm1Schm/\Drd2^+ \Drd3^tm1Schm/\Drd3^tm1Schm	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3623128
cx8	\Drd1^tm1Jcd/\Drd1^tm1Jcd \Drd2^tm1Ebo/\Drd2^+	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6	MGI:4440953

Genotype
MGI:4429670

ht1

• Allelic Composition: \Drd2^tm1Low/\Drd2⁺
• Genetic Background: 129S/Sv-Drd2^tm1Low

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal locomotor behavior ( J:47001 )

• mice exhibit decreased horizontal distance compared with 129S/SvEv mice

Genotype
MGI:3719696

ht2

• Allelic Composition: \Drd2^{tm1(IL2RA)Koba}/\Drd2⁺
• Genetic Background: B6.129P2-Drd2^{tm1(IL2RA)Koba}

behavior/neurological

abnormal locomotor activation ( J:85929 )

• after methamphetamine treatment, mice exhibit less of an increase in movement relative to wild-type mice

• mice exhibit a greater amount of spontaneous movement

unidirectional circling ( J:85929 )

• following treatment with IT injection, mice turn more towards the side of injection relative to wild-type mice and the direction of turning could be reversed by methamphetamine treatment

• following treatment with IT injection and treatment with apomorphine mice turn ispilaterally to the injection

nervous system

decreased dopaminergic neuron number ( J:85929 )

• following treatment with IT injection, the number of D2R containing neurons are 2.6% of that in wild-type mice

Genotype
MGI:4429668

ht3

• Allelic Composition: \Drd2^tm1Low/\Drd2⁺
• Genetic Background: B6.129S2-Drd2^tm1Low

behavior/neurological

behavior/neurological phenotype ( J:50787 )

N • mice exhibit a normal saccharin and quinine preference and locomotor depressant response to SCH-23390 treatment

impaired behavioral response to alcohol ( J:50787 )

• ethanol-treated mice exhibit reduced ataxic response compared with similarly treated wild-type mice

abnormal locomotor behavior ( J:47001 )

• mice exhibit decreased horizontal distance and rearing compared with C57BL/6 mice

ataxia ( J:50787 )

• ethanol-treated mice exhibit reduced ataxic response compared with similarly treated wild-type mice

decreased vertical activity ( J:47001 )

decreased locomotor activity ( J:50787 )

cardiovascular system

abnormal systemic arterial blood pressure ( J:103181 )

• mice exhibit increased blood pressure compared with wild-type mice

• however, acute adrenalectomy results in normal blood pressure compared with similarly treated wild-type mice

increased mean systemic arterial blood pressure ( J:103181 )

increased systemic arterial diastolic blood pressure ( J:103181 )

increased systemic arterial systolic blood pressure ( J:103181 )

growth/size/body

increased body weight ( J:103181 )

• compared with wild-type mice or homozygotes

Genotype
MGI:3576287

ht4

• Allelic Composition: \Drd2^tm1Yyw/\Drd2⁺
• Genetic Background: B6.129S4-Drd2^tm1Yyw

behavior/neurological

abnormal behavioral response to xenobiotic ( J:82829 )

• D-amphetamine induced a different pattern of stereotypic behaviors in heterozygotes mice compared to wild-type and homozygous mutant littermates

Genotype
MGI:3615305

ht5

• Allelic Composition: \Drd2^tm1Ebo/\Drd2⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

behavior/neurological

abnormal behavior ( J:96229 )

• in a non-selective attention test, mice exhibit higher scanning times (measured by duration of individual rearing episodes) during the first and second part of the test compared with wild-type mice

decreased vertical activity ( J:29045 )

• heterozygotes exhibit a significant reduction in vertical activity (rearing) in the open-field test relative to wild-type mice

decreased locomotor activity ( J:96229 , J:29045 )

• during the first part of the test (J:96229)

• heterozygotes show a significant reduction in locomotion in the open-field test, though of a lesser magnitude than that observed in homozygous mutant mice (J:29045)

catalepsy ( J:29045 )

• heterozygotes display a significant increase in cataleptic-like behavior in the ring test, though of a lesser magnitude than that observed in homozygous mutant mice

Genotype
MGI:4429666

ht6

• Allelic Composition: \Drd2^tm1Low/\Drd2⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

behavior/neurological

abnormal locomotor behavior ( J:47001 )

• mice exhibit abnormal motor function with reduced horizontal distance, initiation of movement, time in motion, and number of rearing events compared with C57BL/6 mice

• mice treated with SKF38393 and quinpirole exhibit increased horizontal distance compared with similarly treated wild-type mice

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:47001 )

• mice treated with SKF38393 and quinpirole exhibit increased horizontal distance compared with similarly treated wild-type mice

Genotype
MGI:3623128

cx7

• Allelic Composition: \Drd2^tm1Schm/\Drd2⁺; \Drd3^tm1Schm/\Drd3^tm1Schm
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

behavior/neurological

abnormal locomotor behavior ( J:79483 )

• male mice 70 days old show decreased locomotor activity and distance traveled compared to wild-type but these parameters are still significantly greater than double homozygotes

Genotype
MGI:4440953

cx8

• Allelic Composition: \Drd1^tm1Jcd/\Drd1^tm1Jcd; \Drd2^tm1Ebo/\Drd2⁺
• Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

mortality/aging

premature death ( J:91781 )

• mutant mice do not survive the postweaning period unless given highly hydrated food

• when fed a normal breeder diet, only 50% of mutants survive to P25 but none survive to P50

• when fed a semiliquid diet, 86% of mutantss survive to P25 and 69% survive to P50

• however, when the semiliquid feeding regimen is discontinued, mutant mice lose weight and eventually die within 2-3 days

growth/size/body

postnatal growth retardation ( J:91781 )

• mutant mice fed a normal breeder diet fail to thrive after weaning whereas those fed a semiliquid diet grow at a significantly reduced rate relative to wild-type controls

behavior/neurological

abnormal eating behavior ( J:91781 )

digestive/alimentary system

gastrointestinal hemorrhage ( J:91781 )

• at 21 days of age, mutant mice fed with a normal breeder diet display hemorrhages in the digestive tract

intestinal ulcer ( J:91781 )

• mutant mice fed a normal breeder diet display multiple chronic small intestine ulcers accompanied by intense hemorrhage

• however, no ulcers or intense hemorrhage are observed when mutant mice are fed a semiliquid diet

abnormal duodenum morphology ( J:91781 )

• mutant mice fed with breeder diet display a severe villous atrophy in the duodenum

• lethal ulcerations appear to be prevented by a semiliquid diet

abnormal stomach morphology ( J:91781 )

• no food is ever found in mutant stomachs despite food ingestion

small intestinal inflammation ( J:91781 )

• mutant mice fed a normal breeder diet display severe ulcerative jejunoileitis, characterized by multiple chronic small intestine ulcers and bleeding

• histological changes are pronounced in the duodenum and upper jejunum, less prominent in the lower jejunum, and nearly absent in the ileum

immune system

small intestinal inflammation ( J:91781 )

• mutant mice fed a normal breeder diet display severe ulcerative jejunoileitis, characterized by multiple chronic small intestine ulcers and bleeding

• histological changes are pronounced in the duodenum and upper jejunum, less prominent in the lower jejunum, and nearly absent in the ileum

cardiovascular system

gastrointestinal hemorrhage ( J:91781 )

• at 21 days of age, mutant mice fed with a normal breeder diet display hemorrhages in the digestive tract