All Phenotypes Robo1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Robo1⁺
wild type
MGI:2435634

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Robo1^em1(IMPC)Mbp/Robo1⁺	C57BL/6N-Robo1^em1(IMPC)Mbp/MbpMmucd	MGI:6461615
ht2	Robo1^tm1Phr/Robo1⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3806464

Allelic Composition	Robo1^em1(IMPC)Mbp/Robo1⁺
Genetic Background	C57BL/6N-Robo1^em1(IMPC)Mbp/MbpMmucd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo1^em1(IMPC)Mbp mutation (1 available); any Robo1 mutation (88 available)

Data Sources

IMPC Data for Robo1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:211773 )

IMPC - UCD

decreased thigmotaxis ( J:211773 )

IMPC - UCD

decreased locomotor activity ( J:211773 )

IMPC - UCD

no spontaneous movement ( J:211773 )

IMPC - UCD

Allelic Composition	Robo1^tm1Phr/Robo1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo1^tm1Phr mutation (0 available); any Robo1 mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased lymphoma incidence ( J:93666 )

• spontaneously develop lung lymphomas and carcinomas during the second year of life with a 3-fold increase in incidence compared with controls

increased carcinoma incidence ( J:93666 )

• spontaneously develop lung lymphomas and carcinomas during the second year of life with a 3-fold increase in incidence compared with controls

increased lung adenocarcinoma incidence ( J:93666 )

• 26.5% of tumors that develop in heterozygotes are lung adenocarcinomas

respiratory system

increased lung adenocarcinoma incidence ( J:93666 )

• 26.5% of tumors that develop in heterozygotes are lung adenocarcinomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:93666

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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