Phenotypes associated with this allele

• Allele Symbol: Axin2⁺
• Allele Name: wild type
• Allele ID: MGI:2435592
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Axin2^M1J/Axin2^+	C57BL/6J-Axin2^M1J/GrsrJ	MGI:5659868
ht2	Axin2^tm1b(KOMP)Wtsi/Axin2^+	C57BL/6N-Axin2^tm1b(KOMP)Wtsi/Bay	MGI:6261942
ht3	Axin2^em1Fstl/Axin2^+	involves: C57BL/6J * C57BL/6JIcoCrlLumc * CBA/J	MGI:6115023
ht4	Axin2^M1J/Axin2^+	involves: C57BL/6J * FVB/NJ	MGI:5659869
cn5	Axin2^tm1.1(cre/ERT2/tdTomato)Eem/Axin2^+ Ctnnb1^tm2Kem/Ctnnb1^tm2Kem	involves: 129S2/SvPas * C57BL/6	MGI:5532656
cx6	Axin2^tm1Wbm/Axin2^+ Tg(Wt1-Sox9)92Asc/?	involves: 129 * C57BL/6	MGI:3795285

Genotype
MGI:5659868

ht1

• Allelic Composition: Axin2^M1J/Axin2⁺
• Genetic Background: C57BL/6J-Axin2^M1J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

kinked tail ( J:223644 )

• heterozygotes have a noticably kinked tail and the tail length varies with the amount of kinking of the tail

mortality/aging

prenatal lethality, incomplete penetrance ( J:223644 )

• fewer than the expected number of heterozygotes are produced from C57BL/6J x heterozygote or heterozygote x C57BL/6J crosses

Genotype
MGI:6261942

ht2

• Allelic Composition: Axin2^{tm1b(KOMP)Wtsi}/Axin2⁺
• Genetic Background: C57BL/6N-Axin2^{tm1b(KOMP)Wtsi}/Bay
• Cell Lines: EPD0685_5_F12

Data Sources

IMPC Data for Axin2

behavior/neurological

unresponsive to tactile stimuli ( J:211773 )

IMPC - BCM

cardiovascular system

abnormal retina blood vessel morphology ( J:211773 )

♀

IMPC - BCM

growth/size/body

decreased body length ( J:211773 )

♀

IMPC - BCM

homeostasis/metabolism

increased blood urea nitrogen level ( J:211773 )

♀

IMPC - BCM

integument

abnormal skin coloration ( J:211773 )

♀

IMPC - BCM

vision/eye

abnormal retina blood vessel morphology ( J:211773 )

♀

IMPC - BCM

persistence of hyaloid vascular system ( J:211773 )

♂

IMPC - BCM

Genotype
MGI:6115023

ht3

• Allelic Composition: Axin2^em1Fstl/Axin2⁺
• Genetic Background: involves: C57BL/6J * C57BL/6JIcoCrlLumc * CBA/J

growth/size/body

postnatal growth retardation ( J:252680 )

• phenotype is milder than in homozygote

limbs/digits/tail

curly tail ( J:252680 )

• phenotype is milder than in homozygote

Genotype
MGI:5659869

ht4

• Allelic Composition: Axin2^M1J/Axin2⁺
• Genetic Background: involves: C57BL/6J * FVB/NJ

limbs/digits/tail

kinked tail ( J:223644 )

mortality/aging

prenatal lethality, incomplete penetrance ( J:223644 )

• on an F1 background of C57BL/6J and FVB/NJ only 13 of 8 offspring from heterozygote x wildtype had tail kinks and when these were backcrossed to C57BL/6J for a background of approximately 75% C57BL/6J only 33 of 91 had tail kinks

Genotype
MGI:5532656

cn5

• Allelic Composition: Axin2^{tm1.1(cre/ERT2/tdTomato)Eem}/Axin2⁺; Ctnnb1^tm2Kem/Ctnnb1^tm2Kem
• Genetic Background: involves: 129S2/SvPas * C57BL/6

cellular

decreased cell proliferation ( J:204142 )

• epidermis where Ctnnb1 is deleted (following tamoxifen induction) exhibits significantly reduced cell proliferation (>40%) relative to control epidermis

Genotype
MGI:3795285

cx6

• Allelic Composition: Axin2^tm1Wbm/Axin2⁺; Tg(Wt1-Sox9)92Asc/?
• Genetic Background: involves: 129 * C57BL/6

reproductive system

abnormal sex gland morphology ( J:133933 )

• XX gonads that normally stain blue with the Axin2^tm1Jbeh allele fail to stain in the presence of the transgene

endocrine/exocrine glands

abnormal sex gland morphology ( J:133933 )

• XX gonads that normally stain blue with the Axin2^tm1Jbeh allele fail to stain in the presence of the transgene