Phenotypes associated with this allele

• Allele Symbol: Slc6a2⁺
• Allele Name: wild type
• Allele ID: MGI:2435584
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Slc6a2^tm1.1Mkh/Slc6a2^+	B6.129S6-Slc6a2^tm1.1Mkh	MGI:5516191
ht2	Slc6a2^tm1b(EUCOMM)Hmgu/Slc6a2^+	C57BL/6N-Slc6a2^tm1b(EUCOMM)Hmgu/H	MGI:5797822

Genotype
MGI:5516191

ht1

• Allelic Composition: Slc6a2^tm1.1Mkh/Slc6a2⁺
• Genetic Background: B6.129S6-Slc6a2^tm1.1Mkh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavioral despair ( J:200046 )

• decreased mobility in the tail suspension test

increased anxiety-related response ( J:200046 )

• in an elevated plus maze, mice spend less time in open arms and more time in closed arms, freezing incidence and duration of freezing and fewer head dips than wild-type mice

increased thigmotaxis ( J:200046 )

• in an open field

homeostasis/metabolism

abnormal noradrenaline level ( J:200046 )

♂ • increased in the urine of male, but not female, mice

increased circulating noradrenaline level ( J:200046 )

• in some mice

cardiovascular system

cardiovascular system phenotype ( J:200046 )

N • mice exhibit normal blood pressure and baroreflex sensitivity

increased heart rate ( J:200046 )

• over both a 24 hr period and at night

nervous system

nervous system phenotype ( J:200046 )

N • mice exhibit normal baroreflex sensitivity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
heart conduction disease		DOID:10273		J:200046

Genotype
MGI:5797822

ht2

• Allelic Composition: Slc6a2^{tm1b(EUCOMM)Hmgu}/Slc6a2⁺
• Genetic Background: C57BL/6N-Slc6a2^{tm1b(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0649_1_F02

Data Sources

IMPC Data for Slc6a2

hematopoietic system

decreased hemoglobin content ( J:211773 )

♂

IMPC - HAR

homeostasis/metabolism

impaired glucose tolerance ( J:211773 )

♂

IMPC - HAR