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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdc25a+
wild type
MGI:2435447
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Cdc25aGt(OST186277)Lex/Cdc25a+ involves: 129S5/SvEvBrd * C57BL/6J MGI:3609659
cx2
 		Cdc25atm1Kiyo/Cdc25a+
Tg(MMTV-vHaras)SH1Led/? 		involves: 129/Sv * C57BL/6 * C57BL/6J * CD-1 MGI:3718002
cx3
 		Cdc25atm1Kiyo/Cdc25a+
Tg(MMTV-Myc)141-3Led/? 		involves: 129/Sv * C57BL/6 * C57BL/6J * CD-1 MGI:3718004
cx4
 		Cdc25atm1Kiyo/Cdc25a+
Tg(MMTV-Erbb2)NK1Mul/? 		involves: 129/Sv * C57BL/6 * FVB/N MGI:3718003


Genotype
MGI:3609659
ht1
Allelic
Composition		 Cdc25aGt(OST186277)Lex/Cdc25a+
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc25aGt(OST186277)Lex mutation (2 available); any Cdc25a mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal trabecular bone morphology ( J:103485 )
• male heterozygotes exhibited decreased vertebral trabecular bone volume, number, and thickness




Genotype
MGI:3718002
cx2
Allelic
Composition		 Cdc25atm1Kiyo/Cdc25a+
Tg(MMTV-vHaras)SH1Led/?
Genetic
Background		 involves: 129/Sv * C57BL/6 * C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc25atm1Kiyo mutation (0 available); any Cdc25a mutation (31 available)
Tg(MMTV-vHaras)SH1Led mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased incidence of induced tumors ( J:123144 )
• mice develop mammary and salivary tumors with a latency of 60 weeks compared to 18 weeks in Tg(MMTV-vHaras)SH1Led transgenic mice
• 10% of mice do not develop tumors within 2 years of observation




Genotype
MGI:3718004
cx3
Allelic
Composition		 Cdc25atm1Kiyo/Cdc25a+
Tg(MMTV-Myc)141-3Led/?
Genetic
Background		 involves: 129/Sv * C57BL/6 * C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc25atm1Kiyo mutation (0 available); any Cdc25a mutation (31 available)
Tg(MMTV-Myc)141-3Led mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:123144 )
N
• tumorigenesis is similar to in Tg(MMTV-Myc)141-3Led transgenic mice




Genotype
MGI:3718003
cx4
Allelic
Composition		 Cdc25atm1Kiyo/Cdc25a+
Tg(MMTV-Erbb2)NK1Mul/?
Genetic
Background		 involves: 129/Sv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc25atm1Kiyo mutation (0 available); any Cdc25a mutation (31 available)
Tg(MMTV-Erbb2)NK1Mul mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased incidence of induced tumors ( J:123144 )
• mice develop tumors at a latency of 32 weeks compared to 23 weeks in Tg(MMTV-Erbb2)NK1Mul transgenic mice
• mice do not develop hyperplastic nodules in mammary glands as do Tg(MMTV-Erbb2)NK1Mul transgenic mice

cellular
decreased cell proliferation ( J:123144 )
• fewer cells are in S-phase and proliferation is decreased compared to in Tg(MMTV-Erbb2)NK1Mul transgenic mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory