Phenotypes associated with this allele

• Allele Symbol: Pomc⁺
• Allele Name: wild type
• Allele ID: MGI:2435408
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Pomc^em1(IMPC)Rbrc/Pomc^+	C57BL/6NJcl-Pomc^em1(IMPC)Rbrc/Rbrc	MGI:7415018
ht2	Pomc^tm2Ute/Pomc^+	involves: 129S1/Sv * 129X1/SvJ	MGI:3804423
ht3	Pomc^tm1Sora/Pomc^+	involves: 129S2/SvHsd * 129S6/SvEvTac	MGI:3041651
ht4	Pomc^tm1Low/Pomc^+	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2	MGI:4833834
cx5	Pomc^tm1Low/Pomc^+ Tg(Pomc)#Low/0	involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster	MGI:4833836

Genotype
MGI:7415018

ht1

• Allelic Composition: Pomc^{em1(IMPC)Rbrc}/Pomc⁺
• Genetic Background: C57BL/6NJcl-Pomc^{em1(IMPC)Rbrc}/Rbrc

Data Sources

IMPC Data for Pomc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

enlarged spleen ( J:211773 )

♀

IMPC - RBRC

hematopoietic system

abnormal spleen morphology ( J:211773 )

♀

IMPC - RBRC

enlarged spleen ( J:211773 )

♀

IMPC - RBRC

homeostasis/metabolism

impaired glucose tolerance ( J:211773 )

♂

IMPC - RBRC

immune system

abnormal spleen morphology ( J:211773 )

♀

IMPC - RBRC

enlarged spleen ( J:211773 )

♀

IMPC - RBRC

Genotype
MGI:3804423

ht2

• Allelic Composition: Pomc^tm2Ute/Pomc⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

homeostasis/metabolism

increased circulating leptin level ( J:57503 )

growth/size/body

growth/size/body region phenotype ( J:57503 )

N • although serum leptin levels are increased, mutants do not show an increase in body weight

Genotype
MGI:3041651

ht3

• Allelic Composition: Pomc^tm1Sora/Pomc⁺
• Genetic Background: involves: 129S2/SvHsd * 129S6/SvEvTac

pigmentation

diluted coat color ( J:89244 )

• lighter ventral coat color than that of wild-type

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:89244 )

decreased circulating corticosterone level ( J:89244 )

• decreased, in spite of normal adrenal gland structure

growth/size/body

increased susceptibility to diet-induced obesity ( J:89244 )

integument

integument phenotype ( J:89244 )

N • normal pigmentation

diluted coat color ( J:89244 )

• lighter ventral coat color than that of wild-type

Genotype
MGI:4833834

ht4

• Allelic Composition: Pomc^tm1Low/Pomc⁺
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

neoplasm

increased pituitary adenoma incidence ( J:119240 )

• melanotroph adenomas

nervous system

increased pituitary adenoma incidence ( J:119240 )

• melanotroph adenomas

endocrine/exocrine glands

increased pituitary adenoma incidence ( J:119240 )

• melanotroph adenomas

Genotype
MGI:4833836

cx5

• Allelic Composition: Pomc^tm1Low/Pomc⁺; Tg(Pomc)#Low/0
• Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

neoplasm

increased pituitary adenoma incidence ( J:119240 )

• melanotroph adenomas

nervous system

increased pituitary adenoma incidence ( J:119240 )

• melanotroph adenomas

endocrine/exocrine glands

increased pituitary adenoma incidence ( J:119240 )

• melanotroph adenomas