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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Casc3+
wild type
MGI:2435366
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Casc3tm1.1(KOMP)Vlcg/Casc3+ C57BL/6NCrl-Casc3tm1.1(KOMP)Vlcg/MbpMmucd MGI:7751920
ht2
Casc3Gt(RRU345)Byg/Casc3+ involves: 129P2/OlaHsd * C57BL/6J MGI:5888878
ht3
Casc3tm1(KOMP)Vlcg/Casc3+ involves: C57BL/6J * C57BL/6NTac MGI:5888880


Genotype
MGI:7751920
ht1
Allelic
Composition
Casc3tm1.1(KOMP)Vlcg/Casc3+
Genetic
Background
C57BL/6NCrl-Casc3tm1.1(KOMP)Vlcg/MbpMmucd
Cell Lines 11788B-H10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casc3tm1.1(KOMP)Vlcg mutation (1 available); any Casc3 mutation (41 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism

reproductive system




Genotype
MGI:5888878
ht2
Allelic
Composition
Casc3Gt(RRU345)Byg/Casc3+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casc3Gt(RRU345)Byg mutation (0 available); any Casc3 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• at E13.5, heterozygous embryos are grossly normal with no overt body or brain size reduction relative to wild-type controls
• brains show no ectopic neuron production at E12.5 or extensive apoptosis at E14.5




Genotype
MGI:5888880
ht3
Allelic
Composition
Casc3tm1(KOMP)Vlcg/Casc3+
Genetic
Background
involves: C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casc3tm1(KOMP)Vlcg mutation (1 available); any Casc3 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• heterozygous mutant embryos exhibit normal size and morphology at E10.5; no overt reduction in brain size is noted at E11.5 or E12.5





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory