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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rorc+
wild type
MGI:2435299
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Id2tm1Yyk/Id2tm1Yyk
Rorctm2Litt/Rorc+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4357864
cx2
 		Ltatm1Dch/Ltatm1Dch
Rorctm2Litt/Rorc+ 		involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:3054104


Genotype
MGI:4357864
cx1
Allelic
Composition		 Id2tm1Yyk/Id2tm1Yyk
Rorctm2Litt/Rorc+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2tm1Yyk mutation (0 available); any Id2 mutation (17 available)
Rorctm2Litt mutation (2 available); any Rorc mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal gut-associated lymphoid tissue morphology ( J:87395 )
• absence of lymphoid tissue inducer (LTi) cells
abnormal immune system cell morphology ( J:87395 )
• lack of CD11b+ cells in E16.5 fetuses
abnormal lymph organ development ( J:87395 )
• absence of lymphoid tissue inducer (LTi) cells

digestive/alimentary system
abnormal gut-associated lymphoid tissue morphology ( J:87395 )
• absence of lymphoid tissue inducer (LTi) cells




Genotype
MGI:3054104
cx2
Allelic
Composition		 Ltatm1Dch/Ltatm1Dch
Rorctm2Litt/Rorc+
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltatm1Dch mutation (2 available); any Lta mutation (20 available)
Rorctm2Litt mutation (2 available); any Rorc mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal gut-associated lymphoid tissue morphology ( J:91566 )
• mature intestinal cryptopatches fail to form

digestive/alimentary system
abnormal gut-associated lymphoid tissue morphology ( J:91566 )
• mature intestinal cryptopatches fail to form




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory