Analysis Tools|
Allele Symbol Allele Name Allele ID |
Plp1+ wild type MGI:2435270 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• activated microglia containing lipid and/or membranous inclusions are found, although they are not a marked feature, and there appears to be an increase in glial cell number at 50 and 90 days of age
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• although degenerative changes are not found in either oligodendrocytes or astrocytes, many oligodendrocytes appear to be metabolically active, having prominant rough endoplasmic reticulum and Golgi apparatus, and there is an increase in oligodendrocyte number although to a lesser degree than in hemizyogus males
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• the spinal cord has some sheaths with uncompacted myelin or intramyelinic vacuolation and folds of redundant myelin are more common than in wild-type males
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• spinal cord of heterozygous females has fibres with disproportionately thin myelin sheaths for the axon diameters although no large hypomyelinated patches are found, the mean myelin thickness in adult ventral columns is reduced, and naked axons can be found in the ventral columns of younger mice but are infrequent in older mice
• optic nerve has lower myelin density, although the mean myelin thickness and axon diameter are normal
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• activated microglia containing lipid and/or membranous inclusions are found, although they are not a marked feature, and there appears to be an increase in glial cell number at 50 and 90 days of age
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• activated microglia containing lipid and/or membranous inclusions are found, although they are not a marked feature, and there appears to be an increase in glial cell number at 50 and 90 days of age
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• activated microglia containing lipid and/or membranous inclusions are found, although they are not a marked feature, and there appears to be an increase in glial cell number at 50 and 90 days of age
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• although degenerative changes are not found in either oligodendrocytes or astrocytes, many oligodendrocytes appear to be metabolically active, having prominant rough endoplasmic reticulum and Golgi apparatus, and there is an increase in oligodendrocyte number although to a lesser degree than in hemizyogus males
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• a mosaic of normally myelinated axons and axons abnormally surrounded by oligodendrocyte membranes (similar to homozygous mice) is seen
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• a mosaic of normally myelinated axons and axons abnormally surrounded by oligodendrocyte membranes (similar to homozygous mice) is seen
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• a mosaic of normally myelinated axons and axons abnormally surrounded by oligodendrocyte membranes (similar to homozygous mice) is seen
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• a mosaic of normally myelinated axons and axons abnormally surrounded by oligodendrocyte membranes (similar to homozygous mice) is seen
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• axonal swelling and degeneration are seen but less frequently than in hemizygous males; however all optic nerve axons have normal myelin sheaths
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die at 7 - 12 months of age later than males
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• progressive motor impairments similar to males but milder at 4 - 6 weeks of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 01/28/2026 MGI 6.24 |
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