All Phenotypes Hnf4a<+> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hnf4a⁺
wild type
MGI:2435120

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hnf4a^{tm1b(EUCOMM)Hmgu}/Hnf4a⁺	C57BL/6N-Hnf4a^{tm1b(EUCOMM)Hmgu}/Ieg	MGI:6262634
ht2	Hnf4a^tm1(cre)Sdv/Hnf4a⁺	involves: 129S/SvEv * CD-1	MGI:3053216
cn3	Hnf4a^tm1(cre)Sdv/Hnf4a⁺ Myc^tm2.1Atp/Myc^tm2.1Atp	involves: 129P2/OlaHsd * 129S/SvEv	MGI:3811917

Allelic Composition	Hnf4a^{tm1b(EUCOMM)Hmgu}/Hnf4a⁺
Genetic Background	C57BL/6N-Hnf4a^{tm1b(EUCOMM)Hmgu}/Ieg
Cell Lines	HEPD0635_7_A08

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hnf4a^{tm1b(EUCOMM)Hmgu} mutation (1 available); any Hnf4a mutation (28 available)

Data Sources

IMPC Data for Hnf4a

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:211773 )

IMPC - HMGU

abnormal retina blood vessel morphology ( J:211773 )

IMPC - HMGU

endocrine/exocrine glands

enlarged thyroid gland ( J:211773 )

IMPC - HMGU

growth/size/body

decreased body weight ( J:211773 )

IMPC - HMGU

homeostasis/metabolism

decreased circulating creatinine level ( J:211773 )

IMPC - HMGU

increased circulating bilirubin level ( J:211773 )

IMPC - HMGU

increased circulating cholesterol level ( J:211773 )

IMPC - HMGU

increased circulating HDL cholesterol level ( J:211773 )

IMPC - HMGU

increased circulating calcium level ( J:211773 )

IMPC - HMGU

vision/eye

abnormal lens morphology ( J:211773 )

IMPC - HMGU

cataract ( J:211773 )

IMPC - HMGU

persistence of hyaloid vascular system ( J:211773 )

IMPC - HMGU

abnormal retina morphology ( J:211773 )

IMPC - HMGU

abnormal retina vasculature morphology ( J:211773 )

IMPC - HMGU

abnormal retina blood vessel morphology ( J:211773 )

IMPC - HMGU

increased total retina thickness ( J:211773 )

IMPC - HMGU

Allelic Composition	Hnf4a^tm1(cre)Sdv/Hnf4a⁺
Genetic Background	involves: 129S/SvEv * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hnf4a^tm1(cre)Sdv mutation (2 available); any Hnf4a mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:92294 )

• cre expression occurred in the liver, gut epithelium and kidney in late gestation embryos and post natal mice

Allelic Composition	Hnf4a^tm1(cre)Sdv/Hnf4a⁺ Myc^tm2.1Atp/Myc^tm2.1Atp
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hnf4a^tm1(cre)Sdv mutation (2 available); any Hnf4a mutation (28 available)
Myc^tm2.1Atp mutation (0 available); any Myc mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:137630 )

N	• mice are viable

liver/biliary system

liver/biliary system phenotype ( J:137630 )

N	• liver size and morphology are normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/06/2026 MGI 6.29