All Phenotypes Tert<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tert⁺
wild type
MGI:2435085

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	\Tert^tm1Leah/\Tert⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:3841482
ht2	\Tert^tm1Yjc/\Tert⁺	involves: C57BL/6 * SPRET/Ei	MGI:3053682
cn3	\Pten^tm1Rdp/\Pten^tm1Rdp \Tert^tm1Rdp/\Tert⁺ \Trp53^tm1Brn/\Trp53^tm1Brn \Tg(Pbsn-cre)4Prb/0	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:5431944

Allelic Composition	\Tert^tm1Leah/\Tert⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tert^tm1Leah mutation (1 available); any Tert mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

aneuploidy ( J:90866 )

• late passages of heterozygous mutant ES cells display increased aneuploidy relative to wild-type ES cells

abnormal telomere length ( J:90866 )

• late passages (P25 and P50) but not early passages (P1) of heterozygous mutant ES cells show a modest reduction in telomeric restriction fragment (TRF) length by pulsed-field gel electrophoresis; not observed in early or late passages of wild-type ES cells

• P50 but not P1 heterozygous mutant ES cells show decreased telomere signal intensity at some chromosome ends, as shown by FISH analysis on metaphase spreads

• however, no end-to-end chromosomal fusions are detected in P50 heterozygous mutant ES cells, despite the presence of shortened telomeres

Allelic Composition	\Tert^tm1Yjc/\Tert⁺
Genetic Background	involves: C57BL/6 * SPRET/Ei

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tert^tm1Yjc mutation (1 available); any Tert mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:92243 )

N	• telomere length is unaffected

Allelic Composition	\Pten^tm1Rdp/\Pten^tm1Rdp \Tert^tm1Rdp/\Tert⁺ \Trp53^tm1Brn/\Trp53^tm1Brn \Tg(Pbsn-cre)4Prb/0
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Rdp mutation (0 available); any Pten mutation (87 available)
Tert^tm1Rdp mutation (0 available); any Tert mutation (54 available)
Tg(Pbsn-cre)4Prb mutation (3 available)
Trp53^tm1Brn mutation (21 available); any Trp53 mutation (249 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:186105 )

neoplasm

increased prostate gland adenocarcinoma incidence ( J:186105 )

• all develop rapidly progressive, locally invasive prostate adenocarcinomas

increased prostate intraepithelial neoplasia incidence ( J:186105 )

• high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age

reproductive system

increased prostate gland adenocarcinoma incidence ( J:186105 )

• all develop rapidly progressive, locally invasive prostate adenocarcinomas

increased prostate intraepithelial neoplasia incidence ( J:186105 )

• high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:186105 )

• all develop rapidly progressive, locally invasive prostate adenocarcinomas

increased prostate intraepithelial neoplasia incidence ( J:186105 )

• high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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