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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sumo1+
wild type
MGI:2435057
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Sumo1tm1.1(KOMP)Vlcg/Sumo1+ C57BL/6N-Sumo1tm1.1(KOMP)Vlcg/Ucd MGI:6263610
ht2
 		Sumo1Gt(RRQ016)Byg/Sumo1+ involves: 129P2/OlaHsd * C57BL/6J MGI:3712503
cx3
 		Eya1tm1Rilm/Eya1+
Sumo1Gt(RRQ016)Byg/Sumo1+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3712507


Genotype
MGI:6263610
ht1
Allelic
Composition		 Sumo1tm1.1(KOMP)Vlcg/Sumo1+
Genetic
Background		 C57BL/6N-Sumo1tm1.1(KOMP)Vlcg/Ucd
Cell Lines 19033A-B4
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sumo1tm1.1(KOMP)Vlcg mutation (1 available); any Sumo1 mutation (67 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
enlarged heart ( J:211773 )
IMPC - UCD

growth/size/body
enlarged heart ( J:211773 )
IMPC - UCD




Genotype
MGI:3712503
ht2
Allelic
Composition		 Sumo1Gt(RRQ016)Byg/Sumo1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sumo1Gt(RRQ016)Byg mutation (1 available); any Sumo1 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:112841 )
• a level of embryonic death is noted between E13.5 and E18.5
• genotypic distribution at P1 differs from expected 1:2:1
neonatal lethality, incomplete penetrance ( J:112841 )
• immediate postnatal death is observed with some pups
• genotypic distribution at P1 differs from expected 1:2:1

normal phenotype
no abnormal phenotype detected ( J:141678 )
• contrary to an earlier report, heterozygous mice display no abnormal phenotype

craniofacial
cleft secondary palate ( J:112841 )
• 8.7% of heterozygous pups and embryos display cleft palate or oblique facial cleft
oblique facial cleft ( J:112841 )
• 8.7% of heterozygous pups and embryos display cleft palate or oblique facial cleft

digestive/alimentary system
cleft secondary palate ( J:112841 )
• 8.7% of heterozygous pups and embryos display cleft palate or oblique facial cleft

growth/size/body
cleft secondary palate ( J:112841 )
• 8.7% of heterozygous pups and embryos display cleft palate or oblique facial cleft
oblique facial cleft ( J:112841 )
• 8.7% of heterozygous pups and embryos display cleft palate or oblique facial cleft




Genotype
MGI:3712507
cx3
Allelic
Composition		 Eya1tm1Rilm/Eya1+
Sumo1Gt(RRQ016)Byg/Sumo1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eya1tm1Rilm mutation (1 available); any Eya1 mutation (57 available)
Sumo1Gt(RRQ016)Byg mutation (1 available); any Sumo1 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft secondary palate ( J:112841 )
• cleft palate occurs with 36% frequency (4/11 heterozygotes) compared to 8.7% in Sumo1 single heterozygotes

digestive/alimentary system
cleft secondary palate ( J:112841 )
• cleft palate occurs with 36% frequency (4/11 heterozygotes) compared to 8.7% in Sumo1 single heterozygotes

growth/size/body
cleft secondary palate ( J:112841 )
• cleft palate occurs with 36% frequency (4/11 heterozygotes) compared to 8.7% in Sumo1 single heterozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory