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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fzd1+
wild type
MGI:2435047
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Fzd1tm1.1Nat/Fzd1+
Vangl2Lp/Vangl2+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ MGI:4838143
cx2
 		Fzd1tm1.1Nat/Fzd1+
Fzd2tm1.1Nat/Fzd2+
Vangl2Lp/Vangl2+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ MGI:4838144
cx3
 		Fzd1tm1.1Nat/Fzd1+
Fzd2tm1.1Nat/Fzd2tm1.1Nat 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:4838141


Genotype
MGI:4838143
cx1
Allelic
Composition		 Fzd1tm1.1Nat/Fzd1+
Vangl2Lp/Vangl2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd1tm1.1Nat mutation (1 available); any Fzd1 mutation (30 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
open neural tube ( J:165556 )
• in 12 of 27 mice, more common in the rostral neural tube

cardiovascular system
ventricular septal defect ( J:165556 )
• muscular and/or membranous in mice with neural tube defects

nervous system
open neural tube ( J:165556 )
• in 12 of 27 mice, more common in the rostral neural tube




Genotype
MGI:4838144
cx2
Allelic
Composition		 Fzd1tm1.1Nat/Fzd1+
Fzd2tm1.1Nat/Fzd2+
Vangl2Lp/Vangl2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd1tm1.1Nat mutation (1 available); any Fzd1 mutation (30 available)
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (32 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
open neural tube ( J:165556 )
• in 4 of 7 mice, more common in the rostral neural tube

cardiovascular system
ventricular septal defect ( J:165556 )
• muscular and/or membranous in mice with neural tube defects

nervous system
open neural tube ( J:165556 )
• in 4 of 7 mice, more common in the rostral neural tube




Genotype
MGI:4838141
cx3
Allelic
Composition		 Fzd1tm1.1Nat/Fzd1+
Fzd2tm1.1Nat/Fzd2tm1.1Nat
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd1tm1.1Nat mutation (1 available); any Fzd1 mutation (30 available)
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:165556 )
• in 1 of 6 mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory