All Phenotypes Fgf10<+> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Fgf10^Mhdaaey17/Fgf10⁺	C3HeB/FeJ-Fgf10^Mhdaaey17	MGI:4398721
ht2	Fgf10^{tm1b(EUCOMM)Wtsi}/Fgf10⁺	C57BL/6N-Fgf10^{tm1b(EUCOMM)Wtsi}/H	MGI:5757112
ht3	Fgf10^tm1Wss/Fgf10⁺	involves: 129 * 129X1/SvJ * BALB/c * C57BL/6	MGI:3775808
ht4	Fgf10^tm1Wss/Fgf10⁺	involves: 129X1/SvJ	MGI:5816495
ht5	Fgf10^Mhdaaey17/Fgf10⁺	involves: C3HeB/FeJ * C57BL/6	MGI:4398722
ht6	Fgf10^tm1Ska/Fgf10⁺	involves: C57BL/6 * CBA	MGI:3775805
cn7	Fgf10^tm1Wss/Fgf10⁺ Fgfr2^tm2Dsn/Fgfr2⁺ Tg(Pgk1-cre)1Lni/0	involves: 129 * 129X1/SvJ * BALB/c * C57BL/6	MGI:3775807
cn8	Fgf10^tm1Ska/Fgf10⁺ Fgf8^tm1Moon/Fgf8^tm1Moon Mesp1^tm2(cre)Ysa/Mesp1⁺	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5661384
cx9	Fgf3^tm1Mrc/Fgf3^tm1Mrc Fgf10^tm1Wss/Fgf10⁺	involves: 129S7/SvEvBrd * 129X1/SvJ	MGI:3662760

Allelic Composition	Fgf10^Mhdaaey17/Fgf10⁺
Genetic Background	C3HeB/FeJ-Fgf10^Mhdaaey17

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10^Mhdaaey17 mutation (1 available); any Fgf10 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:154551 )

N	• mice exhibit normal eye size, cornea, lens, and viterous

abnormal lens morphology ( J:154551 )

• at E17.5, lens nuclei are not distributed on the central lens area unlike in wild-type mice

abnormal lens epithelium morphology ( J:154551 )

• thickened at E17.5

abnormal lens fiber morphology ( J:154551 )

• swollen at E17.5

microphthalmia ( J:86685 , J:154551 )

• at E17.5 but not at later time points (J:154551)

narrow eye opening ( J:154551 )

endocrine/exocrine glands

Harderian gland atrophy ( J:154551 )

• the Harderian gland is severely reduced and is seen as a fibrotic, pigmented mass with only a few remaining alveoli lined by epithelial cells with cytoplasmic fat vacuoles (foamy cells) unlike in wild-type mice

Allelic Composition	Fgf10^{tm1b(EUCOMM)Wtsi}/Fgf10⁺
Genetic Background	C57BL/6N-Fgf10^{tm1b(EUCOMM)Wtsi}/H
Cell Lines	EPD0378_4_A02

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10^{tm1b(EUCOMM)Wtsi} mutation (0 available); any Fgf10 mutation (31 available)

Data Sources

IMPC Data for Fgf10

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:211773 )

IMPC - HAR

behavior/neurological

abnormal behavior ( J:211773 )

IMPC - HAR

decreased thigmotaxis ( J:211773 )

IMPC - HAR

impaired pupillary reflex ( J:211773 )

IMPC - HAR

decreased grip strength ( J:211773 )

IMPC - HAR

decreased locomotor activity ( J:211773 )

IMPC - HAR

growth/size/body

decreased lean body mass ( J:211773 )

IMPC - HAR

hematopoietic system

decreased leukocyte cell number ( J:211773 )

IMPC - HAR

homeostasis/metabolism

increased circulating cholesterol level ( J:211773 )

IMPC - HAR

increased circulating HDL cholesterol level ( J:211773 )

IMPC - HAR

immune system

decreased leukocyte cell number ( J:211773 )

IMPC - HAR

vision/eye

impaired pupillary reflex ( J:211773 )

IMPC - HAR

abnormal cornea morphology ( J:211773 )

IMPC - HAR

cornea opacity ( J:211773 )

IMPC - HAR

narrow eye opening ( J:211773 )

IMPC - HAR

Allelic Composition	Fgf10^tm1Wss/Fgf10⁺
Genetic Background	involves: 129 * 129X1/SvJ * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10^tm1Wss mutation (0 available); any Fgf10 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Submandibular gland is hypoplastic in Fgfr2^tm2Dsn/Fgfr2⁺ Tg(Pgk1-cre)1Lni/0, Fgf10^tm1Wss/Fgf10⁺, and Fgf10^tm1Wss/Fgf10⁺ Fgfr2^tm2Dsn/Fgfr2⁺ Tg(Pgk1-cre)1Lni/0 mice

endocrine/exocrine glands

submandibular gland hypoplasia ( J:119849 )

digestive/alimentary system

submandibular gland hypoplasia ( J:119849 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal nasal gland morphology ( J:237227 )

• branching of the maxillary sinus gland, lateral nasal glands, and medial nasal glands is reduced at E17.5

abnormal lateral nasal gland morphology ( J:237227 )

• branching of the lateral nasal glands is reduced at E17.5

• at E17.5, the Steno's gland (lateral nasal gland 1) is developed and elongates to the correct location under the maxillary sinus, however, the extent of branching is reduced

abnormal sublingual gland morphology ( J:299375 )

• sublingual gland weight is decreased in 7-10-week old mice

• sublingual glands exhibit smaller glandular lobes in 7-10-week old mice

• however, glands show no morphological differences in histology

abnormal submandibular gland development ( J:299375 )

• mice show a delay in submandibular gland development

• E12.5 explant culture of submandibular glands show smaller epithelial prebud-like invaginations of the epithelium and this delay in development continues with reduced branching

• at E14.5, the epithelium fails to invade the most aboral part of the mesenchymal capsule in culture

• the epithelium of the mesenchymal capsule of the submandibular gland is less developed at E14.5, with fewer branches, larger epithelial buds and more extensive areas of mesenchyme not invaded by the epithelium

decreased submandibular gland size ( J:299375 )

• submandibular gland and sublingual gland weight is decreased in 7-10-week old mice

• submandibular glands exhibit smaller glandular lobes in 7-10-week old mice

• however, glands show no morphological differences in histology

small salivary gland ( J:299375 )

• the overall size of salivary gland lobes appears smaller and weight is reduced at P14

• males have larger glands compared to females

decreased salivation ( J:299375 )

• mice show a reduction in saliva flow from both the submandibular gland and parotid gland

• mice show a reduction in the salivary pellicle on the tongue; mice treated with HCl to remove the mucus from the oral surface show complete removal of mucus unlike wild-type mice that show sheets of mucus remaining

xerostomia ( J:299375 )

behavior/neurological

polydipsia ( J:299375 )

craniofacial

reduced enamel thickness ( J:299375 )

• mice exhibit less enamel than controls and teeth of many mice show severe tooth wear, with almost complete loss of the cusp pattern in the most severe cases, due to reduced saliva

xerostomia ( J:299375 )

abnormal nasal gland morphology ( J:237227 )

• branching of the maxillary sinus gland, lateral nasal glands, and medial nasal glands is reduced at E17.5

abnormal lateral nasal gland morphology ( J:237227 )

• branching of the lateral nasal glands is reduced at E17.5

• at E17.5, the Steno's gland (lateral nasal gland 1) is developed and elongates to the correct location under the maxillary sinus, however, the extent of branching is reduced

digestive/alimentary system

abnormal sublingual gland morphology ( J:299375 )

• sublingual gland weight is decreased in 7-10-week old mice

• sublingual glands exhibit smaller glandular lobes in 7-10-week old mice

• however, glands show no morphological differences in histology

abnormal submandibular gland development ( J:299375 )

• mice show a delay in submandibular gland development

• E12.5 explant culture of submandibular glands show smaller epithelial prebud-like invaginations of the epithelium and this delay in development continues with reduced branching

• at E14.5, the epithelium fails to invade the most aboral part of the mesenchymal capsule in culture

decreased submandibular gland size ( J:299375 )

• submandibular gland and sublingual gland weight is decreased in 7-10-week old mice

• submandibular glands exhibit smaller glandular lobes in 7-10-week old mice

• however, glands show no morphological differences in histology

small salivary gland ( J:299375 )

• the overall size of salivary gland lobes appears smaller and weight is reduced at P14

• males have larger glands compared to females

decreased salivation ( J:299375 )

• mice show a reduction in saliva flow from both the submandibular gland and parotid gland

xerostomia ( J:299375 )

growth/size/body

reduced enamel thickness ( J:299375 )

• mice exhibit less enamel than controls and teeth of many mice show severe tooth wear, with almost complete loss of the cusp pattern in the most severe cases, due to reduced saliva

xerostomia ( J:299375 )

abnormal nasal gland morphology ( J:237227 )

• branching of the maxillary sinus gland, lateral nasal glands, and medial nasal glands is reduced at E17.5

abnormal lateral nasal gland morphology ( J:237227 )

• branching of the lateral nasal glands is reduced at E17.5

• at E17.5, the Steno's gland (lateral nasal gland 1) is developed and elongates to the correct location under the maxillary sinus, however, the extent of branching is reduced

homeostasis/metabolism

decreased salivation ( J:299375 )

• mice show a reduction in saliva flow from both the submandibular gland and parotid gland

xerostomia ( J:299375 )

respiratory system

abnormal nasal gland morphology ( J:237227 )

• branching of the maxillary sinus gland, lateral nasal glands, and medial nasal glands is reduced at E17.5

abnormal lateral nasal gland morphology ( J:237227 )

• branching of the lateral nasal glands is reduced at E17.5

• at E17.5, the Steno's gland (lateral nasal gland 1) is developed and elongates to the correct location under the maxillary sinus, however, the extent of branching is reduced

skeleton

reduced enamel thickness ( J:299375 )

• mice exhibit less enamel than controls and teeth of many mice show severe tooth wear, with almost complete loss of the cusp pattern in the most severe cases, due to reduced saliva

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lacrimoauriculodentodigital syndrome 1		DOID:0050331	OMIM:149730	J:237227

Allelic Composition	Fgf10^Mhdaaey17/Fgf10⁺
Genetic Background	involves: C3HeB/FeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10^Mhdaaey17 mutation (1 available); any Fgf10 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina apoptosis ( J:154551 )

• at P1, some mice exhibit bulges in the retina unlike in wild-type mice

• however, eyes are normal at P7

abnormal lens fiber morphology ( J:154551 )

• at P7, lens fiber cell nuclei are more diffuse compared to in wild-type mice

cellular

abnormal retina apoptosis ( J:154551 )

• at P1, some mice exhibit bulges in the retina unlike in wild-type mice

• however, eyes are normal at P7

Allelic Composition	Fgf10^tm1Ska/Fgf10⁺
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10^tm1Ska mutation (1 available); any Fgf10 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Hypoplastic submandibular glands are seen in Fgfr2^tm1.1Dsn/Fgfr2⁺ and Fgf10^tm1Ska/Fgf10⁺ mice

endocrine/exocrine glands

abnormal submandibular duct morphology ( J:119849 )

• at E13.5, glands show fewer ducts and terminal buds

submandibular gland hypoplasia ( J:119849 )

• submandibular salivary gland branching hypoplasia at E13.5

digestive/alimentary system

abnormal submandibular duct morphology ( J:119849 )

• at E13.5, glands show fewer ducts and terminal buds

submandibular gland hypoplasia ( J:119849 )

• submandibular salivary gland branching hypoplasia at E13.5

growth/size/body

decreased body weight ( J:200882 )

respiratory system

abnormal forced expiratory flow rates ( J:200882 )

• decrease in forced expiratory volume in 75 ms (FEV75), forced vital capacity (FVC) and FEV75/FVC quota

• however, lung morphology and histopathology appear normal and lung/body weight ratio is normal

Allelic Composition	Fgf10^tm1Wss/Fgf10⁺ Fgfr2^tm2Dsn/Fgfr2⁺ Tg(Pgk1-cre)1Lni/0
Genetic Background	involves: 129 * 129X1/SvJ * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10^tm1Wss mutation (0 available); any Fgf10 mutation (31 available)
Fgfr2^tm2Dsn mutation (0 available); any Fgfr2 mutation (88 available)
Tg(Pgk1-cre)1Lni mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Submandibular gland is hypoplastic in Fgfr2^tm2Dsn/Fgfr2⁺ Tg(Pgk1-cre)1Lni/0, Fgf10^tm1Wss/Fgf10⁺, and Fgf10^tm1Wss/Fgf10⁺ Fgfr2^tm2Dsn/Fgfr2⁺ Tg(Pgk1-cre)1Lni/0 mice

endocrine/exocrine glands

abnormal submandibular duct morphology ( J:119849 )

• submandibular salivary glands exhibit fewer ducts and terminal buds than either single heterozygous mutant

decreased submandibular gland size ( J:119849 )

• submandibular salivary glands are smaller than either single heterozygous mutant

digestive/alimentary system

abnormal submandibular duct morphology ( J:119849 )

• submandibular salivary glands exhibit fewer ducts and terminal buds than either single heterozygous mutant

decreased submandibular gland size ( J:119849 )

• submandibular salivary glands are smaller than either single heterozygous mutant

Allelic Composition	Fgf10^tm1Ska/Fgf10⁺ Fgf8^tm1Moon/Fgf8^tm1Moon Mesp1^tm2(cre)Ysa/Mesp1⁺
Genetic Background	involves: C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10^tm1Ska mutation (1 available); any Fgf10 mutation (31 available)
Fgf8^tm1Moon mutation (1 available); any Fgf8 mutation (21 available)
Mesp1^tm2(cre)Ysa mutation (3 available); any Mesp1 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal aortic arch morphology ( J:170879 )

• narrow

aberrant origin of the right subclavian artery ( J:170879 )

right aortic arch ( J:170879 )

abnormal common carotid artery morphology ( J:170879 )

• absence of the left common carotid artery in some mice

abnormal cardiovascular development ( J:170879 )

abnormal pharyngeal arch artery morphology ( J:170879 )

• various defects are detected at E10.5, including missing third, fourth and sixth PAAs and retention of the second PAA

• incidence of defects is increased compared to mutant mice wild-type for Fgf10

abnormal fourth pharyngeal arch artery morphology ( J:170879 )

abnormal sixth pharyngeal arch artery morphology ( J:170879 )

abnormal third pharyngeal arch artery morphology ( J:170879 )

abnormal cardiac outflow tract development ( J:170879 )

• hypomorphic at E9.5

• more severe than in mutant mice wild-type for Fgf10

double outlet right ventricle ( J:170879 )

• more frequent than in mutant mice wild-type for Fgf10

ventricular septal defect ( J:170879 )

• more frequent than in mutant mice wild-type for Fgf10

decreased heart right ventricle size ( J:170879 )

• hypomorphic at E9.5

• more severe than in mutant mice wild-type for Fgf10

craniofacial

abnormal pharyngeal arch artery morphology ( J:170879 )

• various defects are detected at E10.5, including missing third, fourth and sixth PAAs and retention of the second PAA

• incidence of defects is increased compared to mutant mice wild-type for Fgf10

abnormal fourth pharyngeal arch artery morphology ( J:170879 )

abnormal sixth pharyngeal arch artery morphology ( J:170879 )

abnormal third pharyngeal arch artery morphology ( J:170879 )

second pharyngeal arch hypoplasia ( J:170879 )

third pharyngeal arch hypoplasia ( J:170879 )

embryo

abnormal pharyngeal arch artery morphology ( J:170879 )

• various defects are detected at E10.5, including missing third, fourth and sixth PAAs and retention of the second PAA

• incidence of defects is increased compared to mutant mice wild-type for Fgf10

abnormal fourth pharyngeal arch artery morphology ( J:170879 )

abnormal sixth pharyngeal arch artery morphology ( J:170879 )

abnormal third pharyngeal arch artery morphology ( J:170879 )

second pharyngeal arch hypoplasia ( J:170879 )

third pharyngeal arch hypoplasia ( J:170879 )

Allelic Composition	Fgf3^tm1Mrc/Fgf3^tm1Mrc Fgf10^tm1Wss/Fgf10⁺
Genetic Background	involves: 129S7/SvEvBrd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10^tm1Wss mutation (0 available); any Fgf10 mutation (31 available)
Fgf3^tm1Mrc mutation (0 available); any Fgf3 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal otic vesicle development ( J:83659 )

• otic vesicles are more ventrally localized than in controls

small otic vesicle ( J:83659 )

• small otic vesicles at E9.5; phenotype is more severe than in mutants homozygous for Fgf10 and heterozygous for Fgf3

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