Analysis Tools
behavior/neurological
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• despite increased social investigation, mice perform normally in hidden food reward tests and test order habituation indicating normal olfactory function
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• mice exhibit decreased ability to remember familiar objects compared to wild-type mice
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• mice exhibit impaired performance in a rotarod test only after 12 trials
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• mice fail to exhibit a decrease in exploration of an intruder mouse upon re-exposure until the fourth re-exposure unlike wild-type mice
• in a social versus non-social stimuli test, mice exhibit a preference for non-social stimuli unlike wild-type mice
• however, treatment of mice by prior injections of cholinesterase inhibitors restores normal socialization to repeated exposure to an intruder mouse
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nervous system
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• smaller than in wild-type mice
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• extracellular acetylcholine levels are depressed more than 35% in the frontal cortex and about 31% in the striatum compared to wild-type mice
• KCL stimulated release of acetylcholine is reduced relative to in wild-type mice
• acetylcholine levels in the brain are increased 49% compared to in wild-type mice due to reduced release
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