Phenotypes associated with this allele

• Allele Symbol: Stag1⁺
• Allele Name: wild type
• Allele ID: MGI:2434865
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Stag1^em1(IMPC)Mbp/Stag1^+	C57BL/6N-Stag1^em1(IMPC)Mbp/MbpMmucd	MGI:6480597
ht2	Stag1^Gt(P099A04)Wrst/Stag1^+	involves: 129S2/SvPas	MGI:5446710

Genotype
MGI:6480597

ht1

• Allelic Composition: Stag1^em1(IMPC)Mbp/Stag1⁺
• Genetic Background: C57BL/6N-Stag1^em1(IMPC)Mbp/MbpMmucd

Data Sources

IMPC Data for Stag1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal placenta vasculature ( J:211773 )

IMPC - UCD

embryo

abnormal placenta morphology ( J:211773 )

IMPC - UCD

abnormal placenta vasculature ( J:211773 )

IMPC - UCD

endocrine/exocrine glands

enlarged seminal vesicle ( J:211773 )

♂

IMPC - UCD

growth/size/body

enlarged kidney ( J:211773 )

♂

IMPC - UCD

enlarged spleen ( J:211773 )

♀

IMPC - UCD

hematopoietic system

abnormal spleen morphology ( J:211773 )

♀

IMPC - UCD

enlarged spleen ( J:211773 )

♀

IMPC - UCD

small spleen ( J:211773 )

♂

IMPC - UCD

homeostasis/metabolism

increased circulating triglyceride level ( J:211773 )

♂

IMPC - UCD

immune system

abnormal spleen morphology ( J:211773 )

♀

IMPC - UCD

enlarged spleen ( J:211773 )

♀

IMPC - UCD

small spleen ( J:211773 )

♂

IMPC - UCD

abnormal lymph node morphology ( J:211773 )

♀

IMPC - UCD

enlarged lymph nodes ( J:211773 )

♀

IMPC - UCD

renal/urinary system

abnormal kidney morphology ( J:211773 )

♀

IMPC - UCD

enlarged kidney ( J:211773 )

♂

IMPC - UCD

small kidney ( J:211773 )

♀

IMPC - UCD

abnormal urinary bladder morphology ( J:211773 )

♂

IMPC - UCD

reproductive system

enlarged seminal vesicle ( J:211773 )

♂

IMPC - UCD

vision/eye

microphthalmia ( J:211773 )

♀

IMPC - UCD

Genotype
MGI:5446710

ht2

• Allelic Composition: Stag1^{Gt(P099A04)Wrst}/Stag1⁺
• Genetic Background: involves: 129S2/SvPas

mortality/aging

premature death ( J:184720 )

premature aging ( J:184720 )

• some symptoms of premature aging including acute kyphosis

neoplasm

decreased incidence of tumors by chemical induction ( J:184720 )

• mice are resistant to 3-methyl-colanthrene-induced fibrosarcomas and diethyl-nitrosamine-induced liver tumors

decreased tumor growth/size ( J:184720 )

• reduced cell proliferation in 3-methyl-colanthrene-induced fibrosarcomas

increased tumor incidence ( J:184720 )

• reduced latency and altered tumor spectrum

• tumor incidence is not altered in Trp53 or Pten null backgrounds

increased lymphoma incidence ( J:184720 )

increased histiocytic sarcoma incidence ( J:184720 )

increased carcinoma incidence ( J:184720 )

• hepatocellular carcinoma and vascular carcinomas

increased hepatocellular carcinoma incidence ( J:184720 )

increased papilloma incidence ( J:184720 )

• cystic papillary neoplasm in the pancreas

cellular

abnormal telomere morphology ( J:184720 )

• intermediate fragile telomeres with defective telomere replication

abnormal mitosis ( J:184720 )

• increased frequency od defective anaphase in mouse embryonic fibroblasts and issues

decreased cell proliferation ( J:184720 )

• reduced cell proliferation in 3-methyl-colanthrene-induced fibrosarcomas

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:184720 )

• mice are resistant to 3-methyl-colanthrene-induced fibrosarcomas and diethyl-nitrosamine-induced liver tumors

skeleton

kyphosis ( J:184720 )

• acute

liver/biliary system

increased hepatocellular carcinoma incidence ( J:184720 )