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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Jag2+
wild type
MGI:2434779
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Jag2tm1Grid/Jag2+ involves: 129S1/Sv * C57BL/6J MGI:3691117
cx2
 		Dll1tm1Gos/Dll1+
Jag2tm1Grid/Jag2+ 		involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J MGI:3776431
cx3
 		Dll1tm2Gos/Dll1+
Jag2tm1Grid/Jag2+ 		involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J MGI:3776430


Genotype
MGI:3691117
ht1
Allelic
Composition		 Jag2tm1Grid/Jag2+
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag2tm1Grid mutation (1 available); any Jag2 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased cochlear hair cell number ( J:53432 )
• heterozygotes exhibit a slight but insignificant increase in average IHC density and total number relative to wild-type mice
increased cochlear inner hair cell number ( J:53432 )
• heterozygotes display a relatively high incidence of IHC duplications relative to wild-type mice

nervous system
increased cochlear hair cell number ( J:53432 )
• heterozygotes exhibit a slight but insignificant increase in average IHC density and total number relative to wild-type mice
increased cochlear inner hair cell number ( J:53432 )
• heterozygotes display a relatively high incidence of IHC duplications relative to wild-type mice




Genotype
MGI:3776431
cx2
Allelic
Composition		 Dll1tm1Gos/Dll1+
Jag2tm1Grid/Jag2+
Genetic
Background		 involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Gos mutation (2 available); any Dll1 mutation (45 available)
Jag2tm1Grid mutation (1 available); any Jag2 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased cochlear inner hair cell number ( J:132241 )
• cochlea possess increased inner hair cells but not as many as in Jag2tm1Grid homozygotes

nervous system
increased cochlear inner hair cell number ( J:132241 )
• cochlea possess increased inner hair cells but not as many as in Jag2tm1Grid homozygotes




Genotype
MGI:3776430
cx3
Allelic
Composition		 Dll1tm2Gos/Dll1+
Jag2tm1Grid/Jag2+
Genetic
Background		 involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm2Gos mutation (0 available); any Dll1 mutation (45 available)
Jag2tm1Grid mutation (1 available); any Jag2 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased cochlear inner hair cell number ( J:132241 )
• cochlea possess increased inner hair cells but not as many as in Jag2tm1Grid homozygotes

nervous system
increased cochlear inner hair cell number ( J:132241 )
• cochlea possess increased inner hair cells but not as many as in Jag2tm1Grid homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory