All Phenotypes Jag2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Jag2⁺
wild type
MGI:2434779

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Jag2^tm1Grid/Jag2⁺	involves: 129S1/Sv * C57BL/6J	MGI:3691117
cx2	Dll1^tm1Gos/Dll1⁺ Jag2^tm1Grid/Jag2⁺	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J	MGI:3776431
cx3	Dll1^tm2Gos/Dll1⁺ Jag2^tm1Grid/Jag2⁺	involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J	MGI:3776430

Allelic Composition	Jag2^tm1Grid/Jag2⁺
Genetic Background	involves: 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag2^tm1Grid mutation (1 available); any Jag2 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

increased cochlear hair cell number ( J:53432 )

• heterozygotes exhibit a slight but insignificant increase in average IHC density and total number relative to wild-type mice

increased cochlear inner hair cell number ( J:53432 )

• heterozygotes display a relatively high incidence of IHC duplications relative to wild-type mice

nervous system

increased cochlear hair cell number ( J:53432 )

• heterozygotes exhibit a slight but insignificant increase in average IHC density and total number relative to wild-type mice

increased cochlear inner hair cell number ( J:53432 )

• heterozygotes display a relatively high incidence of IHC duplications relative to wild-type mice

Allelic Composition	Dll1^tm1Gos/Dll1⁺ Jag2^tm1Grid/Jag2⁺
Genetic Background	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1^tm1Gos mutation (2 available); any Dll1 mutation (46 available)
Jag2^tm1Grid mutation (1 available); any Jag2 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

increased cochlear inner hair cell number ( J:132241 )

• cochlea possess increased inner hair cells but not as many as in Jag2^tm1Grid homozygotes

increased cochlear outer hair cell number ( J:132241 )

nervous system

increased cochlear inner hair cell number ( J:132241 )

• cochlea possess increased inner hair cells but not as many as in Jag2^tm1Grid homozygotes

increased cochlear outer hair cell number ( J:132241 )

Allelic Composition	Dll1^tm2Gos/Dll1⁺ Jag2^tm1Grid/Jag2⁺
Genetic Background	involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1^tm2Gos mutation (0 available); any Dll1 mutation (46 available)
Jag2^tm1Grid mutation (1 available); any Jag2 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

increased cochlear inner hair cell number ( J:132241 )

• cochlea possess increased inner hair cells but not as many as in Jag2^tm1Grid homozygotes

increased cochlear outer hair cell number ( J:132241 )

nervous system

increased cochlear inner hair cell number ( J:132241 )

• cochlea possess increased inner hair cells but not as many as in Jag2^tm1Grid homozygotes

increased cochlear outer hair cell number ( J:132241 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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