All Phenotypes Ranbp2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ranbp2⁺
wild type
MGI:2434650

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ranbp2^{Gt(pGT0pfs)630Wcs}/Ranbp2⁺	129P2/OlaHsd-Ranbp2^{Gt(pGT0pfs)630Wcs}	MGI:3694781
ht2	Ranbp2^{tm1.1(KOMP)Vlcg}/Ranbp2⁺	C57BL/6N-Ranbp2^{tm1.1(KOMP)Vlcg}/MbpMmucd	MGI:5887495
ht3	Ranbp2^{Gt(pGT0pfs)630Wcs}/Ranbp2⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:3694782
ht4	Ranbp2^tm1.1Jvd/Ranbp2⁺	involves: 129/Sv * C57BL/6	MGI:3802799

Allelic Composition	Ranbp2^{Gt(pGT0pfs)630Wcs}/Ranbp2⁺
Genetic Background	129P2/OlaHsd-Ranbp2^{Gt(pGT0pfs)630Wcs}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ranbp2^{Gt(pGT0pfs)630Wcs} mutation (0 available); any Ranbp2 mutation (115 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system physiology ( J:116134 )

• Background Sensitivity: reduced levels of ATP in the brain and retina only in mice on an inbred 129P2/OlaHsd background and not in mice on a mixed 129P2/OlaHsd and C57BL/6J background

vision/eye

abnormal rod electrophysiology ( J:116134 )

• reduced a-wave and b-wave amplitudes

• reduction in b-wave responses is greater than that in a-wave responses

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:116134 )

• Background Sensitivity: slower weight gain beginning around 4 months of age when on a high fat diet only in mice on an inbred 129P2/OlaHsd background and not in mice on a mixed 129P2/OlaHsd and C57BL/6J background

• however, no differences in food consumption are detected

impaired glucose tolerance ( J:116134 )

• Background Sensitivity: reduced rates of glucose clearance only in mice on an inbred 129P2/OlaHsd background and not in mice on a mixed 129P2/OlaHsd and C57BL/6J background

• however, gluconeogenesis is similar to wild-type mice

growth/size/body

decreased susceptibility to diet-induced obesity ( J:116134 )

• however, no differences in food consumption are detected

Allelic Composition	Ranbp2^{tm1.1(KOMP)Vlcg}/Ranbp2⁺
Genetic Background	C57BL/6N-Ranbp2^{tm1.1(KOMP)Vlcg}/MbpMmucd
Cell Lines	14451B-F6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ranbp2^{tm1.1(KOMP)Vlcg} mutation (1 available); any Ranbp2 mutation (115 available)

Data Sources

IMPC Data for Ranbp2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal testis morphology ( J:211773 )

IMPC - UCD

small testis ( J:211773 )

IMPC - UCD

reproductive system

abnormal testis morphology ( J:211773 )

IMPC - UCD

small testis ( J:211773 )

IMPC - UCD

abnormal epididymis morphology ( J:211773 )

IMPC - UCD

enlarged epididymis ( J:211773 )

IMPC - UCD

Allelic Composition	Ranbp2^{Gt(pGT0pfs)630Wcs}/Ranbp2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ranbp2^{Gt(pGT0pfs)630Wcs} mutation (0 available); any Ranbp2 mutation (115 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:116134 )

N	• Background Sensitivity: ATP levels in the brain and retina are similar to wild-type mice, unlike heterozygotes on an inbred 129P2/OlaHsd background

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:116134 )

N	• Background Sensitivity: glucose clearance rates are similar to wild-type mice, unlike heterozygotes on an inbred 129P2/OlaHsd background

growth/size/body

growth/size/body region phenotype ( J:116134 )

N	• Background Sensitivity: weight gain on a high fat diet is similar to wild-type mice, unlike heterozygotes on an inbred 129P2/OlaHsd background

Allelic Composition	Ranbp2^tm1.1Jvd/Ranbp2⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ranbp2^tm1.1Jvd mutation (0 available); any Ranbp2 mutation (115 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

aneuploidy ( J:137482 )

• in about 1% of splenocytes

• also range of aneuploidy broadened

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