All Phenotypes Lag3<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lag3⁺
wild type
MGI:2434461

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lag3^tm1Daav/Lag3⁺ Tg(Foxp3-EGFP/cre)1cJbs/0	NOD.Cg-Lag3^tm1Daav Tg(Foxp3-EGFP/cre)1cJbs	MGI:6188326
cx2	Cd4^tm1Doi/Cd4^tm1Litt Lag3^tm1Doi/Lag3⁺	involves: 129 * C57BL/6	MGI:3765245

Allelic Composition	Lag3^tm1Daav/Lag3⁺ Tg(Foxp3-EGFP/cre)1cJbs/0
Genetic Background	NOD.Cg-Lag3^tm1Daav Tg(Foxp3-EGFP/cre)1cJbs

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lag3^tm1Daav mutation (0 available); any Lag3 mutation (37 available)
Tg(Foxp3-EGFP/cre)1cJbs mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to autoimmune diabetes ( J:260063 )

• females exhibit a diabetes incidence of 60% compared to 80-84% in controls

Allelic Composition	Cd4^tm1Doi/Cd4^tm1Litt Lag3^tm1Doi/Lag3⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4^tm1Doi mutation (0 available); any Cd4 mutation (85 available)
Cd4^tm1Litt mutation (2 available); any Cd4 mutation (85 available)
Lag3^tm1Doi mutation (2 available); any Lag3 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased double-negative T cell number ( J:33272 )

• about 3 fold increase in percentage of double negative alpha-beta T cells that are found in the lymph node

• about 4 fold increase in number of double negative alpha-beta T cells that are found in the spleen

• about 5 fold increase in in percentage of double negative alpha-beta T cells that are found in the thymus

abnormal CD4-positive, alpha-beta T cell physiology ( J:33272 )

• impaired T-cell dependent B cell response to foreign antigen

hematopoietic system