All Phenotypes Serpinb5<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Serpinb5⁺
wild type
MGI:2434408

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Serpinb5^tm1Zha/Serpinb5⁺	involves: 129	MGI:3840980

Allelic Composition	Serpinb5^tm1Zha/Serpinb5⁺
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpinb5^tm1Zha mutation (0 available); any Serpinb5 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell adhesion ( J:89192 )

• in vitro, heterozygous mutant visceral endoderm (VE) cells show a decreased ability to attach to a laminin 1 matrix relative to wild-type VE cells

• however, both heterozygous and wild-type VE cells show a similar ability to attach to a fibronectin matrix

decreased cell proliferation ( J:89192 )

• in vitro, heterozygous VE cells show a decreased rate of cell proliferation relative to wild-type VE cells on laminin substrate

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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