All Phenotypes Tradd<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tradd⁺
wild type
MGI:2434276

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tradd^tm1.1Mak/Tradd⁺	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB/N)	MGI:3809720

Allelic Composition	Tradd^tm1.1Mak/Tradd⁺
Genetic Background	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB/N)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tradd^tm1.1Mak mutation (1 available); any Tradd mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased acute inflammation ( J:138824 )

• macrophages produced significantly less TNF when exposed to LPS

• macrophages also produce less TNF in response to the TLR3 agonist poly(I:C)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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