All Phenotypes Kif21a<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kif21a⁺
wild type
MGI:2434266

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Kif21a^{tm1b(EUCOMM)Hmgu}/Kif21a⁺	C57BL/6N-Kif21a^{tm1b(EUCOMM)Hmgu}/J	MGI:6262749
ht2	Kif21a^tm3Ece/Kif21a⁺	involves: 129S1/Sv	MGI:6241438
ht3	Kif21a^tm1.1Ece/Kif21a⁺	involves: 129S1/Sv * 129S4/SvJae	MGI:6241434
cx4	Kif21a^tm1.1Ece/Kif21a⁺ Map1b^tm1Prop/Map1b⁺ Tg(Isl1-EGFP*)1Slp/0	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6	MGI:6241441

Allelic Composition	Kif21a^{tm1b(EUCOMM)Hmgu}/Kif21a⁺
Genetic Background	C57BL/6N-Kif21a^{tm1b(EUCOMM)Hmgu}/J
Cell Lines	HEPD0697_4_H11

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif21a^{tm1b(EUCOMM)Hmgu} mutation (1 available); any Kif21a mutation (80 available)

Data Sources

IMPC Data for Kif21a

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased fasting circulating glucose level ( J:211773 )

IMPC - JAX

Allelic Composition	Kif21a^tm3Ece/Kif21a⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif21a^tm3Ece mutation (0 available); any Kif21a mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:213171 )

• mice are viable and appear phenotypically normal, with no external congenital fibrosis of the extraocular muscles phenotype

Allelic Composition	Kif21a^tm1.1Ece/Kif21a⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif21a^tm1.1Ece mutation (0 available); any Kif21a mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye morphology ( J:213171 )

• mice exhibit unilateral or bilateral ptosis and/or globe retraction that is 43% penetrant and primarily unilateral

blepharoptosis ( J:213171 )

• mice exhibit unilateral or bilateral ptosis and/or globe retraction that is 43% penetrant and primarily unilateral

nervous system

abnormal oculomotor nerve morphology ( J:213171 )

• about 50% of distal oculomotor nerves have only mild proximal thickening and distal thinning compared to wild-type, the other 50% have proximal bulbs and significant distal nerve hypoplasia and branching defects

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital fibrosis of the extraocular muscles		DOID:0080143	OMIM:PS135700	J:213171

Allelic Composition	Kif21a^tm1.1Ece/Kif21a⁺ Map1b^tm1Prop/Map1b⁺ Tg(Isl1-EGFP*)1Slp/0
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif21a^tm1.1Ece mutation (0 available); any Kif21a mutation (80 available)
Map1b^tm1Prop mutation (0 available); any Map1b mutation (85 available)
Tg(Isl1-EGFP*)1Slp mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal abducens nerve morphology ( J:213171 )

• approximately 90% penetrance of abducens nerve hypoplasia

abnormal oculomotor nerve morphology ( J:213171 )

• oculomotor nerve superior branch axons terminate prematurely within a bulb with a penetrance of 90%

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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