About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adm+
wild type
MGI:2434132
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Admtm1Unc/Adm+ 129S6/SvEvTac-Admtm1Unc MGI:3763617
ht2
 		Admtm2Unc/Adm+ 129S6/SvEvTac-Admtm2Unc MGI:3763614
ht3
 		Admtm1Hku/Adm+ involves: 129S6/SvEvTac * C57BL/6 MGI:3043339
ht4
 		Admtm1Tfjt/Adm+ involves: C57BL/6 * CBA MGI:3611560
cx5
 		Admtm1Unc/Adm+
Tg(Alb1-Ren)2Unc/? 		129S6/SvEvTac-Admtm1Unc Tg(Alb1-Ren)2Unc MGI:3763615


Genotype
MGI:3763617
ht1
Allelic
Composition		 Admtm1Unc/Adm+
Genetic
Background		 129S6/SvEvTac-Admtm1Unc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Admtm1Unc mutation (0 available); any Adm mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:125933 )
N
• blood pressure under resting conditions and hypotension induced by pregnancy or after LPS treatment is normal




Genotype
MGI:3763614
ht2
Allelic
Composition		 Admtm2Unc/Adm+
Genetic
Background		 129S6/SvEvTac-Admtm2Unc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Admtm2Unc mutation (0 available); any Adm mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:125933 )
N
• blood pressure under resting conditions is normal




Genotype
MGI:3043339
ht3
Allelic
Composition		 Admtm1Hku/Adm+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Admtm1Hku mutation (0 available); any Adm mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiac hypertrophy ( J:106173 )
• heterozygotes show no significant differences in body size or heart and kidney weight relative to wild-type mice
• however, at 14 days after Ang II infusion, heterozygotes exhibit more severe cardiac hypertrophy than wild-type mice, as shown by a significantly higher increase in heart weight to body weight ratios
increased heart left ventricle wall thickness ( J:106173 )
• at 14 days after angiotensin II (Ang II) infusion, heterozygotes exhibit a significantly increased left ventricular wall thickness relative to wild-type mice (IVST; 1.16 0.09 mm vs 1.06 0.14 mm, respectively)
decreased heart ventricle muscle contractility ( J:106173 )
• heterozygotes exhibit a significantly lower ejection fraction both before and after Ang II infusion
increased systemic arterial blood pressure ( J:89608 )
• original findings indicate that adult heterozygotes show a mild (~10 mmHg) increase in arterial blood pressure relative to wild-type mice, associated with reduced nitric oxide production (J:89608)
• however, subsequent analysis showed no significant differences in systolic blood pressure changes induced by Ang II infusion (J:106173)

growth/size/body
cardiac hypertrophy ( J:106173 )
• heterozygotes show no significant differences in body size or heart and kidney weight relative to wild-type mice
• however, at 14 days after Ang II infusion, heterozygotes exhibit more severe cardiac hypertrophy than wild-type mice, as shown by a significantly higher increase in heart weight to body weight ratios

muscle
decreased heart ventricle muscle contractility ( J:106173 )
• heterozygotes exhibit a significantly lower ejection fraction both before and after Ang II infusion

renal/urinary system
glomerulosclerosis ( J:106173 )
• after Ang II infusion, heterozygotes display a more severe glomerulosclerosis and a higher glomerular injury score than wild-type mice
decreased creatinine clearance ( J:106173 )
• after Ang II infusion, heterozygotes display significantly reduced creatinine clearance relative to wild-type mice
oliguria ( J:106173 )
• heterozygotes exhibit a significantly reduced urine volume relative to wild-type mice
• after Ang II infusion, heterozygotes display a significantly lower increase in urine volume relative to wild-type mice

behavior/neurological
decreased fluid intake ( J:106173 )
• after Ang II infusion, heterozygotes exhibit a significantly lower water intake relative to wild-type mice




Genotype
MGI:3611560
ht4
Allelic
Composition		 Admtm1Tfjt/Adm+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Admtm1Tfjt mutation (0 available); any Adm mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal coronary artery morphology ( J:102946 )
• in severe cases fibrinoid necrosis is seen in the perivascular area of the coronary artery in heterozygous mice given angiotensin II and fed a high salt diet
blood vessel inflammation ( J:102946 )
• inflammation of the perivascular area of the coronary artery is more severe in heterozygous mice given angiotensin II and fed a high salt diet compared to similarly treated wild-type mice

cellular
oxidative stress ( J:102946 )
• elevated urinary excretion of 8-hydroxydeoxyguanosine and isoprostane, elevated expression of Ncf2 and Cybb, and increased 3-nitrotyrosine staining all indicate elevated oxidative stress in the hearts of heterozygous mice given angiotensin II and fed a high salt diet compared to similarly treated wild-type mice

immune system
blood vessel inflammation ( J:102946 )
• inflammation of the perivascular area of the coronary artery is more severe in heterozygous mice given angiotensin II and fed a high salt diet compared to similarly treated wild-type mice




Genotype
MGI:3763615
cx5
Allelic
Composition		 Admtm1Unc/Adm+
Tg(Alb1-Ren)2Unc/?
Genetic
Background		 129S6/SvEvTac-Admtm1Unc Tg(Alb1-Ren)2Unc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Admtm1Unc mutation (0 available); any Adm mutation (12 available)
Tg(Alb1-Ren)2Unc mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased myocardial fiber size ( J:125933 )
• male cardiomyocytes are larger than in Tg(Alb1-Ren)1Unc male mice
• however, there is no difference in cardiomyocyte size in female mice compared to Tg(Alb1-Ren)1Unc female mice
cardiac hypertrophy ( J:125933 )
• male mice exhibit increased cardiac hypertrophy compared to Tg(Alb1-Ren)1Unc male mice
• however, female mice are not significantly different in terms of cardiac hypertrophy compared to female mice containing Tg(Alb1-Ren)1Unc and the degree of coronary artery fibrosis is the same as in Tg(Alb1-Ren)1Unc mice regardless of sex
increased systemic arterial blood pressure ( J:125933 )
• 149+/-12 mmHg compared to 108+/-9 mmHg in wild-type mice
• however, blood pressure is not significantly different from Tg(Alb1-Ren)1Unc containing mice

renal/urinary system
glomerulosclerosis ( J:125933 )
• glomerulosclerosis is worse in male mice than in Tg(Alb1-Ren)1Unc male mice
• however, there is no difference in glomerulosclerosis in female mice compared to Tg(Alb1-Ren)1Unc female mice
renal cast ( J:125933 )
• presence of proteinacious casts is worse in male mice than in Tg(Alb1-Ren)1Unc male mice
• however, there is no difference in presence of proteinacious casts in female mice compared to Tg(Alb1-Ren)1Unc female mice
renal fibrosis ( J:125933 )
• renal fibrosis is worse in male mice than in Tg(Alb1-Ren)1Unc male mice
• however, there is no difference in renal fibrosis in female mice compared to Tg(Alb1-Ren)1Unc female mice

muscle
increased myocardial fiber size ( J:125933 )
• male cardiomyocytes are larger than in Tg(Alb1-Ren)1Unc male mice
• however, there is no difference in cardiomyocyte size in female mice compared to Tg(Alb1-Ren)1Unc female mice

growth/size/body
cardiac hypertrophy ( J:125933 )
• male mice exhibit increased cardiac hypertrophy compared to Tg(Alb1-Ren)1Unc male mice
• however, female mice are not significantly different in terms of cardiac hypertrophy compared to female mice containing Tg(Alb1-Ren)1Unc and the degree of coronary artery fibrosis is the same as in Tg(Alb1-Ren)1Unc mice regardless of sex




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory