Phenotypes associated with this allele

• Allele Symbol: Nfia⁺
• Allele Name: wild type
• Allele ID: MGI:2434131
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Nfia^tm1Rmg/Nfia^+	involves: 129P2/OlaHsd * Black Swiss	MGI:2653058
ht2	Nfia^tm1Rmg/Nfia^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3767252
cx3	Nfia^tm1Rmg/Nfia^+ Tg(Hoxb7-EGFP)33Cos/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3767254

Genotype
MGI:2653058

ht1

• Allelic Composition: Nfia^tm1Rmg/Nfia⁺
• Genetic Background: involves: 129P2/OlaHsd * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

maternal effect ( J:58137 )

• loss of heterozygous progeny is seen only when the mutant allele is transmitted from the female parent, suggesting a maternal effect

Genotype
MGI:3767252

ht2

• Allelic Composition: Nfia^tm1Rmg/Nfia⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Ureter defects in Nfia^tm1Rmg/Nfia^tm1Rmg and Nfia^tm1Rmg/Nifia⁺ mice

renal/urinary system

hydronephrosis ( J:122749 )

• 22% of newborns exhibit hydronephrosis

dilated ureter ( J:122749 )

• newborns exhibit duplication and dilatation of the ureter at the ureteropelvic junction

double ureter ( J:122749 )

• newborns exhibit duplication and dilatation of the ureter at the ureteropelvic junction

abnormal ureterovesical junction morphology ( J:122749 )

• some newborns exhibit dilation of the ureterovesical junction

Genotype
MGI:3767254

cx3

• Allelic Composition: Nfia^tm1Rmg/Nfia⁺; Tg(Hoxb7-EGFP)33Cos/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Nfia^tm1Rmg/Nfia⁺ Tg(Hoxb7-EGFP)33Cos and Nfia^tm1Rmg/Nfia^tm1Rmg Tg(Hoxb7-EGFP)33Cos mice have ureteral defects

renal/urinary system

abnormal ureter development ( J:122749 )

• 22% exhibit ureteral development abnormalities that include ureter dilation and partial ureteral duplication

dilated ureter ( J:122749 )