About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Klc1+
wild type
MGI:2434030
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Klc1tm1Gsn/Klc1+
Tg(APP695)3Dbo/? 		involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6 MGI:3582996


Genotype
MGI:3582996
cx1
Allelic
Composition		 Klc1tm1Gsn/Klc1+
Tg(APP695)3Dbo/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klc1tm1Gsn mutation (1 available); any Klc1 mutation (56 available)
Tg(APP695)3Dbo mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:96346 )
• levels of amyloid beta are consistently elevated relative to controls
abnormal axon morphology ( J:96346 )
• increased axonal swelling independent of amyloid deposition

homeostasis/metabolism
amyloid beta deposits ( J:96346 )
• levels of amyloid beta are consistently elevated relative to controls

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:96346




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory